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Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 62 – No. 4/2024 (155-161)

Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 1: Biogenic components and identification of targets and signaling pathways in amyotrophic lateral sclerosis patients 

Jiacheng Lin¹*, Jun Wang²*, Chenghui Wang², Yuetong Shan², Wei Jing², Zhimin Fei³#⁴, and Weidong Pan²#⁴#⁵

¹Central Laboratory, Science and Technology Laboratory Center, ²Deparment of Neurology, ³Department of Neurosurgery, ⁴Encephalopathy Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, and ⁵First Department of Encephalopathy, Anhui Provincial Hospital of Integrated Chinese and Western Medicine (The Third Affiliated Hospital of Anhui University of Chinese Medicine), Anhui, China
Background: There is evidence that Bu-Shen-Jian-Pi (BSJP), a traditional Chinese medicine, has curative effects in patients suffering from amyotrophic lateral sclerosis (ALS), a progressive and potentially fatal hypoxic condition.
Objective: To identify biogenic components in BSJP extracts having potential pharmacological efficacy in ALS.
Materials and methods: Biogenic components in BSJP and their potential pharmacological targets and signaling pathways in ALS were identified and assessed using network pharmacology/hub node analysis.
Results: Network pharmacology analysis identified icariin, naringenin, kaempferol, quercetin, and formononetin as core components in BSJP with potential activity involving mitochondrial protection in patients with ALS.
Conclusion: Network pharmacology analysis proved to be a successful screening tool for obtaining information from scientific databases on the pharmacology of biogenic components in BSJP showing potential therapeutic activity in ALS.

*Contributed equally.Correspondence to:
Professor Zhimin Fei, MD
or
Professor Weidong Pan, MD, PhD
528, Pudong, New Areas
201203 Shanghai, China
Email: [email protected]; [email protected]

Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 62 – No. 4/2024 (162-168)

Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 2: Modulation of hypoxia, redox status, and mitochondrial protection in a neuroblastoma cell line, SH-SY5Y 

Wenli Yuan¹*, Jiacheng Lin²*, Jun Wang³, Chenghui Wang³, Yuetong Shan³, Wei Jing³, Zhimin Fei⁴#⁵, and Weidong Pan³#⁵#⁶

¹Department of Nephrology Diseases, Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, ²Central Laboratory, Science and Technology Laboratory Center, ³Deparment of Neurology, ⁴Department of Neurosurgery, ⁵Encephalopathy Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, and ⁶First Department of Encephalopathy, Anhui Provincial Hospital of Integrated Chinese and Western Medicine (The Third Affiliated Hospital of Anhui University of Chinese Medicine), Anhui, China
Objective: To examine the mitochondrial protective effects of icariin, naringenin, kaempferol, and formononetin, potentially active agents in Bu-Shen-Jian-Pi formula (BSJP) identified using network pharmacology analysis.
Materials and methods: Mitochondrial protection activity was determined using a hypoxia–reoxygenation in vitro model based on the neuroblastoma cell line SH-SY5Y and measurements of anti-ferroptotic activity.
Results: Icariin, naringenin, kaempferol, and formononetin showed mitochondrial protective activity involving diverse signaling pathways. The cytoprotective effects of formononetin depended on the inhibition of ferroptosis. Hypoxia-reoxygenation stimulation induced ferroptosis in SH-SY5Y cells.
Discussion: Ferroptosis is a key mechanism in nervous system diseases and is associated with hypoxia-reoxygenation injury. Naringenin and kaempferol were devoid of anti-ferroptotic activity.
Conclusion: Evidence has been obtained showing that the core components: icariin, naringenin, kaempferol, and formononetin in BSJP formula have anti-hypoxic and mitochondrial protective activity of potential clinical importance in the treatment of amyotrophic lateral sclerosis and patients with symptoms of hypoxia.

*Contributed equally as co-first authors.Correspondence to:
Professor Zhimin Fei, MD
or
Professor Weidong Pan, MD, PhD
528, Pudong, New Areas
201203 Shanghai, China
Email: [email protected]; [email protected]

Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 64 – No. 1/2026 (38-46)

Amyotrophic lateral sclerosis rehabilitation management and non-pharmacological symptomatic treatment: A review 

Yuetong Shan¹*, Wei Jing¹*, Haihan Zhang¹, Yizhou Liu¹, Shangyu Wei¹, Feifei Wu², and Weidong Pan¹#³

¹Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinses Medicine, ²Department of Neurology, Shanghai Pudong New Area Gongli Hospital, and ³Encephalopathy Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that lacks effective treatment options for the prevention of progression. Relieving swallowing difficulties, reducing breathing difficulties, and alleviating muscle spasms are essential to improving the quality of life in patients with ALS. Many symptoms can be treated clinically with medication; however, the evidence level of related research is relatively low. Rehabilitation management can aid in improving various functional impairments and enhancing quality of life. This review introduces and describes the relevant evaluations of rehabilitation and nonpharmacological symptomatic treatment methods for functional disorders from the perspectives of motor and nonmotor symptoms. This review may promote the popularization of ALS rehabilitation management and provide an additional reference for ALS treatment.

*Yuetong Shan and Wei Jing contributed equally to this work.Correspondence to:
Dr. Feifei Wu
Department of Neurology
Shanghai Pudong New Area Gongli Hospital
Shanghai 200135, China
or
Professor Weidong Pan
Department of Neurology
Shuguang Hospital Affiliated to Shanghai
University of Traditional Chinese Medicine
Shanghai 201203, China
Email: [email protected]; [email protected]

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