Dustri Online Services

Search Results

Books: 0	Journals: 1	Articles: 3

In-depth  Review

Principles responsible for trace element concentrations in chronic kidney disease 

Guido Filler, Yi Qiu, Frederick Kaskel, and Christopher William McIntyre

Volume 96 (2021) p. 1 - 16

Abstract

Clinical Nephrology, Vol. 96 – No. 1/2021 (1-16)

Principles responsible for trace element concentrations in chronic kidney disease 

Guido Filler¹#²#³, Yi Qiu⁴, Frederick Kaskel⁵, and Christopher William McIntyre¹#²#⁶

¹Department of Paediatrics, Division of Nephrology, ²Department of Medicine, ³Department of Pathology and Laboratory Medicine, ⁶Department of Biophysics, ⁴Medical Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, and ⁵Department of Pediatrics, Albert Einstein College of Medicine, Montefiore Health System, Bronx, NY, USA
Derangements of trace elements often occur in patients with renal failure and play a crucial role in chronic kidney disease. The natural history of trace element deposition with worsening chronic kidney disease has been poorly described. Some essential trace elements may get wasted (e.g., selenium, zinc, and manganese) while other trace elements accumulate (e.g., cobalt, lead, molybdenum, and vanadium). Data are most readily available relating to hemodialysis patients. Continuous renal replacement therapies (for the treatment of acute kidney injury) and chronic kidney disease patients without need for renal replacement therapy remain largely unstudied. We have synthesized all available data on mode of absorption and elimination, volume of distribution, plasma protein binding, and proteinuria to summarize the existing literature, identify future areas of research and to allow some prediction of the fate of individual trace elements in clinical scenarios where no direct observational data are available. More prospective studies evaluating the impact of abnormal trace elements and the possible therapeutic value of intervention are required to improve how robust the current international guideline recommendations (KDOQI) are with respect to trace element monitoring.Correspondence to:
 Dr. Guido Filler, MD, PhD, FRCPC
Professor of Pediatrics, Chair/Chief
Department of Pediatrics
University of Western Ontario, Children’s Hospital
London Health Science Centre
800 Commissioners Road East
London, ON, N6A 5W9 Canada
Email: [email protected]

Original

Effects of the pandemic on adolescent and caregiver attitudes towards telemedicine use 

Yi Qiu, Subhrata Verma, Christopher William McIntyre, and Guido Filler

Volume 100 (2023) p. 259 - 268

Abstract

Clinical Nephrology, Vol. 100 – No. 6/2023 (259-268)

Effects of the pandemic on adolescent and caregiver attitudes towards telemedicine use 

Yi Qiu¹, Subhrata Verma², Christopher William McIntyre³#⁴#⁵, and Guido Filler³#⁴

¹Medical Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, ²Hospital for Sick Children, Totonto, Departments of ³Paediatrics, Division of Nephrology, ⁴Medicine, and ⁵Biophysics University of Western Ontario, London, ON, Canada
Background: Telemedicine use increased during the COVID-19 pandemic. We compared both adolescent/caregiver attitudes towards telemedicine pre- and intra-pandemic.
Materials and methods: In a tertiary care setting with a large remote catchment area, we conducted qualitative analysis of structured interviews with dyads of 11 to 18-year-old patients and their caregivers using NVivo during the pandemic and compared the findings to our previous research [1].
Results: We enrolled 14 dyads (35 ± 27 in-person visits and 4 ± 3 telemedicine visits per participant) and compared these with 11 dyads before the pandemic. Adolescents’ mean age was 15.2 ± 2.1 years (range 11.2 – 18.2). The median distance to our medical center was 184.8 km (range 3.9 – 1,214 km, 6 dyads > 100 km). While the preferred ratio of telemedicine to in-person visits was 2 : 1 in caregivers (like pre-pandemic), many emphasized telemedicine as the safer option. Interestingly, adolescents preferred more in-person visits during the pandemic (1 : 1 ratio) compared to pre-pandemic (2 : 1 ratio). Qualitative analysis identified two main themes: consultation-specific factors and contextual factors. Consultation-specific factors were more valued during in-person visits, especially by adolescents. Consultation-specific factors remained the same pre- and post-pandemic, however, adolescents more often emphasized comfort, communication, and personal connection for in-person visits during the pandemic. Contextual factors were valued for telemedicine by adolescents and caregivers, and telemedicine was identified as the norm during the pandemic. Interestingly, the two main contextual themes pre-pandemic: frustration with technological aspects of telemedicine and adolescents not taking telemedicine seriously, disappeared during the pandemic. No disadvantages for telemedicine in the contextual factors were identified during the pandemic.
Conclusion: The COVID-19 pandemic changed the user-expressed attitudes (especially among adolescents) on the transfer to telemedicine for chronic care.Correspondence to:
Guido Filler, MD, PhD, FRCPC
University of Western Ontario
800 Commissioners Road East, E3-206
London, Ontario, Canada N6A 5W9
Email: [email protected]

Original

Associations between atherogenic index of plasma and chronic kidney disease in individuals with hypertension, diabetes mellitus, and hyperuricemia 

Ye Li, Yu-Xuan Zhu, Yi Qiu, and Ya-Yu Li

Volume 105 (2026) p. 117 - 127

Abstract

Clinical Nephrology, Vol. 105 – No. 2/2026 (117-127)

Associations between atherogenic index of plasma and chronic kidney disease in individuals with hypertension, diabetes mellitus, and hyperuricemia 

Ye Li¹, Yu-Xuan Zhu¹, Yi Qiu², and Ya-Yu Li²

¹Department of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, and ²Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China
Objective: The association between the atherogenic index of plasma (AIP) and chronic kidney disease (CKD) among individuals with different metabolic syndromes remains inadequately characterized. The aim of this study is to assess the correlations between AIP and the risk of CKD among individuals diagnosed with hypertension (HTN), diabetes mellitus (DM), and hyperuricemia (HUA).
Materials and methods: Data from the National Health and Nutrition Examination Survey, collected between 2009 and March 2020, were used to categorize eligible participants into HTN, DM, and HUA groups. Weighted logistic regression models and restricted cubic splines were employed to examine the correlations between AIP and CKD. The incremental predictive value of AIP, compared with conventional CKD risk factors, was assessed using the area under the curve, net reclassification improvement index, and integrated discrimination improvement.
Results: Among individuals in the HTN and DM groups, an increase of one unit in AIP was associated with a 17% increase in the risk of CKD (odds ratio (OR): 1.17, 95% confidence interval (CI): 1.10 – 1.25) and a 29% increase (OR: 1.29, 95% CI: 1.18 – 1.40), respectively. Conversely, within the HUA group, neither persistent AIP nor any of the three AIP levels demonstrated a statistically significant correlation with CKD.
Conclusion: The findings demonstrated a significant association between AIP and CKD in individuals with HTN and DM, indicating a potential link between dyslipidemia and CKD risk within these populations. In contrast, AIP did not exhibit a significant association with CKD among individuals with HUA.Correspondence to:
Ya-Yu Li, PhD
Key Laboratory of Kidney Disease Prevention and Control Technology
Department of Nephrology
Hangzhou Hospital of Traditional Chinese Medicine
No. 453 of Tiyuchang Road, Xihu District
Hangzhou 310012, Zhejiang Province, China
Email: [email protected]

Shopping Overview

Shopping Overview
Type	Qtty	Discount	VAT	Price
Your basket is empty

View Cart

Search Results

Shopping Overview

Send us an E-Mail