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Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 54 – No. 12/2016 (1009-1011)

The efficacy of febuxostat 10 mg for the prevention of hyperuricemia associated with tumor lysis syndrome (TLS) in Japanese patients with non-Hodgkin’s lymphoma 

Takeo Yasu, Shunsuke Kobayashi, Mai Horii, Yosuke Kurokawa

Department of Pharmacy, The Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency. The control of serum uric acid level (UA) is important for prevention of TLS. Febuxostat has demonstrated its superiority over allopurinol in decreasing UA level. We retrospectively evaluated the efficacy of febuxostat 10 mg in prevention of hyperuricemia associated with TLS (HU-TLS) in 12 patients with non-Hodgkin’s lymphoma (NHL). Mean UA levels were found to significantly decrease (p = 0.003). HU-TLS was prevented in all patients. Thus, febuxostat 10 mg is effective in prevention of HU-TLS. Future study is need to determine whether the incidence of HU-TLS change with dosage of febuxostat. Correspondence to:
Takeo Yasu, PhD 
The Research Hospital
The Institute of Medical Science
The University of Tokyo
4-6-1, Shirokanedai, Minato-ku,
Tokyo 108-8639, Japan 
Email: yasutakeo-tky@ umin.ac.jp

Abstract

Clinical Nephrology, Vol. 91 – No. 6/2019 – Letters to the editor

Acute kidney injury incidence in patients with hematological malignancy treated with meropenem and vancomycin for febrile neutropenia

Shunsuke Kobayashi, Takeo Yasu, and Kenji Momo

Department of Pharmacy, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan
Correspondence to:
Shunsuke Kobayashi, MSc
Department of Pharmacy
The Institute of Medical Science Hospital
The University of Tokyo
4-6-1, Shirokanedai, Minato-ku,
Tokyo, 108-8639, Japan
Email: [email protected]

Abstract

Clinical Nephrology, Vol. 92 – No. 2/2019 – Letters to the editor

AKI in patients with hematological malignancies treated with various vancomycin-antibiotic combinations

Shunsuke Kobayashi¹#²*, Takeo Yasu¹#³*, and Kenji Momo¹#⁴

¹Department of Pharmacy, The Institute of Medical Science Hospital, The University of Tokyo, ²Department of Pharmacy, Nissan Tamagawa Hospital, ³Department of Medicinal Therapy Research, Meiji Pharmaceutical University, and ⁴Department of Hospital Pharmaceutics, School of Pharmacy, Showa University, Tokyo, Japan

*Contributed equally
Correspondence to:
Shunsuke Kobayashi, MSc
Department of Pharmacy, Nissan Tamagawa Hospital
4-8-1, Seta, Setagaya-ku, Tokyo,158-0095, Japan
Email: [email protected]

Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 59 – No. 9/2021 (627-629)

Efficacy and safety of tedizolid in a patient with linezolid-induced neutropenia: A case report 

Shunsuke Kobayashi¹, Masanori Kase², Masaaki Matsubara², Akira Kitaoka¹, and Takeo Yasu³

¹Department of Pharmacy, Nissan Tamagawa Hospital, Tokyo, ²Department of Orthopedic Surgery, Nissan Tamagawa Hospital, Tokyo, and ³Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, Tokyo, Japan
Linezolid is used to treat prosthetic joint infection after total hip arthroplasty. Here, we present a case of linezolid-induced severe neutropenia, which improved after switching to tedizolid. Grade 3 neutropenia developed 5 days after linezolid injection (1,200 mg/day) and 33 days after oral administration of the same dose. However, during the 70 days of treatment with tedizolid, grade 3 neutropenia did not occur, and C-reactive protein levels remained in the normal range. No grade ≥ 1 thrombocytopenia or bleeding event occurred during the course of tedizolid treatment. Tedizolid may be an alternative drug for patients who develop linezolid-induced neutropenia. Correspondence to:
 Shunsuke Kobayashi, MSc 
Department of  Pharmacy
Nissan Tamagawa Hospital
4-8-1, Seta, Setagaya-ku, Tokyo 158-0095, Japan
Email: shunsukekobayashi0412 @gmail.com

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