Letter to the Editor
Effects of candesartan and amlodipine on renal function and electrolytes in renal allograft recipients
K. Kisters, F. Toknak, M. Kosch, M. Barenbrock and M. Hausberg
Price
42.00 $
Volume 58 (2002) p. 461 - 462
Abstract
K. Kisters, F. Toknak, M. Kosch, M. Barenbrock and M. Hausberg
Letters to the Editor
Evolution of bone stiffness
in renal transplant patients measured by quantitative ultrasound
M. Kosch, K. Kisters and M. Hausberg
Price
42.00 $
Volume 59 (2003) p. 147 - 148
Abstract
M. Kosch, K. Kisters and M. Hausberg
Letters to the Editor
Reply to Mandal
(Clin. Nephrol 60: 372)
K. Kisters, F. Tokmak, M. Kosch and M. Hausberg
Price
42.00 $
Volume 60 (2003) p. 372 - 373
Abstract
K. Kisters, F. Tokmak, M. Kosch and M. Hausberg
Letters to the Editor
Magnesium deficiency and diabetes mellitus
K. Kisters, B. Gremmler, J. Kozianka and M. Hausberg
Price
42.00 $
Volume 65 (2006) p. 77 - 78
Abstract
K. Kisters, B. Gremmler, J. Kozianka and M. Hausberg
Letters to the Editor
Decreased mineral metabolism parameters (magnesium and phosphate) and elevated pulse pressure in hypertension
K. Kisters, B. Gremmler, F. Tokmak, M. Cziborra, C. Funke and M. Hausberg
Price
42.00 $
Volume 68 (2007) p. 130 - 131
Abstract
K. Kisters, B. Gremmler, F. Tokmak, M. Cziborra, C. Funke and M. Hausberg
1Medical Clinic I, St. Anna Hospital Herne, 2Medicaal Clinic, Marienhospital Bottrop, 3Ruhr University Bochum,
4Medical University Policlinic M
Correspondence to:
Prof. Dr. med. K. Kisters
Med. Clinic I, St. Anna Hospital
Hospitalstra
Email: [email protected]
Letter to the Editor
Positive effect of N-acetylcysteine in theophylline intoxication
K. Kisters, M. Cziborra, C. Funke, F. Tokmak and M. Hausberg
Price
42.00 $
Volume 68 (2007) p. 266 - 266
Abstract
K. Kisters, M. Cziborra, C. Funke, F. Tokmak and M. Hausberg
1Med. Clinic I, St. Anna Hospital, Herne, 2Department of Nephrology, Ruhr University Bochum, and 3Department of Nephrology, University Policlinic, M
Correspondence to:
Prof. Dr. K. Kisters
Med. Clinic I, St. Anna Hospital, Hospitalstrasse 19, 44649 Herne, Germany
Email: [email protected]
Originals
Reduced bone mineral density in renal transplanted women – a link to high blood pressure and possibly a disturbed calcium handling
K. Kisters, F. Tokmak, U. Hillebrandt, M.A. Kosch, K.H. Dietl and M. Hausberg
Price
42.00 $
Volume 21 p. 190 - 193
Abstract
K. Kisters1, F. Tokmak1, U. Hillebrandt2, M.A. Kosch2, K.H. Dietl3 and M. Hausberg2
1Department of Internal Medicine I, St. Anna Hospital, Herne,2Medizinische Universitäts-Poliklinik, University of Münster, and 3Department of Surgery, Raphaelsklinik, Münster, Germany
Numerous studies have reported abnormalities in calcium metabolism in human hypertension. However, bone is the largest store of calcium in the body and a loss of mineralization and calcium in connection with an increased 24-h urinary calcium excretion may occur. In this context, it can be speculated that in patients with essential hypertension and lowered bone mineral density the disturbances in calcium metabolism are more pronounced. Especially in hypertensive women with osteoporosis, these factors are of special interest. In this context, measurements of skeletal status after renal transplantation by quantitative ultrasound were performed in 30 patients (12 women) and 25 controls. Bone stiffness was calculated from speed of sound and broadband ultrasound attenuation and no correlation to age, cumulative steroid dose, plasma calcium, or time after transplantation was noted. In a group of hypertensive women (n = 8) after renal transplantation with poor blood pressure control, the age-corrected bone stiffness was measured at 65.5% ± 18.7% at the right calcaneus, and 77.7% ± 19.8% at the left calcaneus. These values were significantly reduced as compared to the entire group of transplant patients (84.8% ± 24.8% and 87.0% ± 28.1%, right and left calcaneus, respectively). In this context, it can be speculated that loss of bone mineral density and hypertension may be connected by abnormalities in calcium metabolism in women.Correspondence to:
Prof. Dr. K. Kisters
Medizinische Klinik I, St. Anna-Hospital
Hospitalstraße 19
D-44649 Herne, Germany
Email: [email protected]
Originals
Iron and ferritin status in hemodialysis patients under darbepoetin alfa therapy
F. Tokmak, K. Kisters, D. Rattensperger, G. Schieren, S. Weiner and L.C. Rump
Price
42.00 $
Volume 21 p. 264 - 273
Abstract
F. Tokmak1, K. Kisters2, D. Rattensperger1, G. Schieren1, S. Weiner1 and L.C. Rump1
1Department of Nephrology, Ruhr-University Bochum, Marienhospital Herne, and 2Med. Clinic I, St. Anna Hospital, Herne, Germany
It is well known, that iron status is often disturbed in patients undergoing regular hemodialysis treatment. Additionally, these patients suffer from anemia due to erythropoietin loss. Darbepoetin alfa therapy is a novel erythropoietin stimulating regimen. Only sparse data exists concerning iron metabolism and demand under darbepoetin alfa therapy. Therefore it was of interest to study iron and ferritin in hemodialysis patients before and after darbepoetin alfa therapy. 29 patients under regular hemodialysis treatment were investigated before and after a 40 weeks’ darbepoetin alfa therapy (10 – 60 mg darbepoetin alfa/week). In each patient iron and ferritin was measured. The results show that iron was 735 ± 364 mg/l before therapy versus 614 ± 242 mg/l after therapy (means ± SD, p < 0.05, paired t-test). Ferritin values were not significantly different (905 ± 394 versus 953 ± 437 mg/l). All patients were on iron supplementation (20 – 120 mg sodium ferric gluconate in sucrose injection per week on average). The results show that iron demand under regular hemodialysis conditions and darbepoetin alfa therapy is increased. Therefore a combined therapy with iron and darbepoetin alfa is necessary in patients undergoing regular hemodialysis treatment.Correspondence to:
Prof. Dr. K. Kisters
St.-Anna-Hospital
Hospitalstrasse 19
D–44649 Herne, Germany
Email: [email protected]
Abstracts
Selenium in the treatment of radiation-associated secondary lymphedema
O. Micke, F. Bruns, R. Mücke, U. Schäfer, M. Glatzel, A.F. DeVries, K. Schönekaes, K. Kisters, and J. Büntzel
Price
42.00 $
Volume 21 p. 277 - 277
Abstract
O. Micke1,4, F. Bruns1,4, R. Mücke2,4, U. Schäfer1,4, M. Glatzel3,4, A.F. DeVries5, K. Schönekaes4, K. Kisters4,6 and J. Büntzel4,7
1Department of Radiotherapy, Münster University Hospital, Münster, 2Department of Radiotherapy, Radiation Oncology and Nuclear Medicine, Weiden Municipal Hospital, 3Department of Radiotherapy, Suhl Central Hospital, Suhl, 4German Working Group Trace Ele
Purpose: The aim of this explorative study was to evaluate the impact of selenium in the treatment of lymphedema after radiotherapy. Methods and materials: Between 6/1996 and 6/2001, 12 patients with arm edema and 36 with edema of the head and neck region were treated with selenium for therapy-related lymphedema. Of these 36 patients, 20 had interstitial endolaryngeal edema associated with stridor and dyspnea. All patients received sodium selenite for 4 – 6 weeks. Results: Self-assessment using a visual analogue scale (n = 48) showed a reduction of 4.3 points when comparing pre- and posttreatment values (p < 0.05). Of 20 patients with endolaryngeal edema, 13 underwent no, 5 a temporary and only 2 a permanent tracheostomy; 10 of 12 patients with arm edema showed a circumference reduction of the edematous limb and improvement in the skin fold index by 23.3 points. An improvement of one stage or more was shown by the Földi or the Miller score (n = 28) in 22 (Földi score) and in 24 (Miller score) patients. Conclusion: Treatment with sodium selenite is well-tolerated and easy to deliver. Additionally, our results suggest that sodium selenite has a positive effect on secondary developing lymphedema caused by radiation therapy alone or irradiation after surgery.
Originals
Does a correlation of NT-proBNP-values exist in comparison to pulse pressure-values?
B. Gremmler, K. Kisters, M. Kunert, H. Schleiting
Price
42.00 $
Volume 22 p. 62 - 65
Abstract
B. Gremmler1, K. Kisters2, M. Kunert1, H. Schleiting1
1Department of Cardiology, Marienhospital Bottrop, Germany,2Internal Medicine, St. Anna-Hospital, Herne, and University of Münster, Germany, and 3University of Witten/Herdecke, Germany
Background: The determination of NT-proBNP- values is increasingly used to distinguish dyspnoea induced by heart failure from pulmonary associated dyspnoea. Furthermore, the course of heart failure is studied with this parameter, especially the effectiveness of heart failure treatment. Similar observations with NT-proBNP-values were increasingly seen in heart failure due to hypertensive origin, in this context especially as a follow up of antihypertensive drug-therapy. In contrast to this biochemical determined parameter the pulse pressure-value exists as a hemodynamic control in treatment of hypertension. Therefore we performed a research on a connection between NT-proBNP-values and pulse pressure-values to prove a possible correlation. Methods: NT-proBNP-levels were analyzed before left-heart catheterization in 100 patients (unselected population; m = 73, w = 27; 61.2 ± 9.7 years). The determination of NT- proBNP in plasma was performed using the electrochemiluminescence technology in the fully automatic Elecsyc®analyser (Roche-Diagnostics) and the Elecsys®proBNP immunoassay (Roche-Diagnostics, Mannheim, Germany). The pulse pressure-value was invasively measured in the aortic arch before application of contrast-medium. The NT-proBNP values were compared to the invasively measured pulse pressure-values accordingly. Results: The NT-proBNP values in correlation to the pulse pressue-values are pointed out in the scatter-diagram. There was no significant correlation between both parameters (coefficent = 0.014). Conclusion: A safe and reliable correlation between NT-proBNP-values and pulse pressue was not found. On the other hand a great variation of NT-proBNP -levels was observed concerning the corresponding pulse pressure values. An augmented NT-proBNP level without correspondance to the pulse pressure value may perhaps be a prognostic marker of an initial heart failure-syndrome induced by hypertension.Correspondence to:
Dr. B. Gremmler,
PD Dr. L. Ulbricht
Marienhospital Bottrop
Department of Cardiology
Josef-Albers-Straße 70
46236 Bottrop, Germany
Email: [email protected]
Originals
Iron and iron-related parameters in oncology
S. Könemann, T. Bölling, F. Matzkies, N. Willich, K. Kisters and O. Micke
Price
42.00 $
Volume 22 p. 142 - 149
Abstract
S. Könemann1, T. Bölling1, F. Matzkies2, N. Willich1, K. Kisters3 and O. Micke1
1Department of Radiotherapy, Münster University Hospital,2Nephrologic Praxis Clinic in the MedicalCenter, Münster, and 3Department of Internal Medicine, St. Anna Hospital, Herne, Germany
Iron is a central element in the metabolism of normal and malignant cells. Besides the oxygen binding, iron plays an important role in many systems like oxygen metabolism, electron transfer via cytochromes and as metal cofactor for enzymes. The iron resorption, the cellular transport, the markers of iron metabolism and storage and their clinical relevance is reviewed. The metabolism of iron is influenced by cellular mechanisms mediated by different cell types like T lymphocytes as well as macrophages and different cytokines like interferon (IFN) g, tumor necrosis factor (TNF) a and interleukin-1 (IL-1) 1. Pathophysiology of iron in chronic infections and tumors, anemia of chronic diseases (ACD) and substitution therapy as well as the impact on the use of erythropoietin are discussed.Correspondence to:
Dr. S. Könemann
Münster University Hospital
Department of Radiotherapy
Albert-Schweitzer-Straße 33
48129 Münster, Germany
Email: [email protected]
Originals
Amifostine and selenium during simultaneous radiochemotherapy in head and neck cancer – redox status data
J. Büntzel, O. Micke, R. Mücke, M. Glatzel, K.G. Schönekaes, U. Schäfer, K. Kisters and F. Bruns
Price
42.00 $
Volume 22 p. 211 - 215
Abstract
J. Büntzel1,3, O. Micke3, R. Mücke3, M. Glatzel2,3, K.G. Schönekaes3, U. Schäfer3, K. Kisters3 and F. Bruns3
1Department of Otolaryngology, Südharz Hospital, Nordhausen, 2Department of Radiotherapy, Central Hospital, Suhl, Germany, and 3The German Working Group “Trace Elements and Electrolytes in Radiation Oncology” (AKTE)
Objective: The supportive strategy of cytoprotection is based on the idea of scavanging free radicals in order to decrease side effects due to anticancer treatment. We have investigated amifostine and sodium selenite regarding its scavanging potential in head and neck cancer patients during radiochemotherapy. Material and methods: One hundred cancer patients received simultaneous radiochemotherapy. During irradiation, 31 patients (Group 1) got 500 µg sodium selenite per day, 29 patients (Group 2) got 500 mg amifostine, and 40 patients (Group 3) got 500 mg sodium selenite and 500 mg amifostine. Amifostine was given at days with chemotherapy only. We measured serum selenium concentration, activity of glutathione peroxidase and concentration of malondialdehyde at the beginning of radiotherapy, after three weeks and at the end of combined treatment. Results: We have seen differences in the serum selenium level of the patients regarding their tumor volume. Sodium selenite, in the amount of 500 mg, was able to correct decreased selenium concentrations within three weeks. The activity of glutathionperoxidase was increased when selenium was substituted. A reduction of malondialdehyde, e.g. aggressive free radicals, were seen in patients with selenium substitution and smaller tumors (Group 1) only. If the tumor volume was larger and the therapy more aggressive, the therapy-induced production of new free radicals was limited (Groups 2 and 3). The combination of sodium selenite and amifostine (Group 3) was more effective than the administration of amifostine alone (Group 2). Conclusion: The substitution of sodium selenite is able to reduce the endogenous level of aggressive free radicals in head and neck cancer patients. Further clinical studies are necessary to evaluate synergisms with other exogenous scavangers of free radicals (for example amifostine) and to evaluate the toxicity-limiting possibilities of this new supportive strategy.Correspondence to:
Dr. J. Büntzel
Klinik für HNO-Erkrankungen, Kopf-Hals-Chirurgie
Südharzkrankenhaus Nordhausen gGmbH
Dr.-Robert-Koch-Straße 39
99734 Nordhausen, Germany
Email: [email protected]
Originals
Plasma magnesium status and pulse pressure in essential hypertension
K. Kisters, O. Hoffmann, M. Hausberg, M. Quang Nguyen, O. Micke and B. Gremmler
Price
42.00 $
Volume 22 p. 254 - 256
Abstract
K. Kisters1, O. Hoffmann1, M. Hausberg1, M. Quang Nguyen1, O. Micke1 and B. Gremmler2
1Medical Clinic I, St. Anna-Hospital, Herne, and 2Cardiological Department, Marienhospital Bottrop, Bottrop, Germany
The influence of a magnesium deficiency in the development of primary hypertension has often been described. However, several investigations were performed in human blood cells or smooth muscle cells in hypertension. Possibly a disturbed calcium/ magnesium antagonism, reduced ATPase activities or disturbed magnesium channels are responsible for this magnesium deficiency. The height of pulse pressure (difference between systolic and diastolic blood pressure values) is known to be a risk factor for cardiovascular morbidity and mortality. In this context, it was of interest to study plasma magnesium concentrations in essential hypertensives with pulse pressure > 60 mmHg and < 50 mmHg (ten patients in each group). Our results show that in the group with a high pulse pressure plasma magnesium concentrations were measured 0.72 ± 0.1 mmol/l versus 0.88 ± 0.07 mmol/l in essential hypertensives with a pulse pressure < 50 mmHg (p < 0.05, r –0,73). In conclusion the presented data shows that in patients with elevated pulse pressure values a magnesium deficiency may occur. The magnesium deficiency significantly correlates with the height of pulse pressure. The results are similar to previous investigations in essential hypertensives. As a benefit of magnesium supplementation has been well documented in the treatment of primary hypertension, further studies are necessary to demonstrate a positive effect of a magnesium therapy in reducing pulse pressure values.Correspondence to:
Prof. K. Kisters
Medical Clinic I
St. Anna-Hospital
Hospitalstraße 19
44649 Herne, Germany
Email: [email protected]
Originals
Trace elements supplementation in radiation oncology – an empirical study assessing the quality of health information for consumers on the World Wide Web in Germany
F. Bruns, R. Mücke, J. Büntzel, K. Kisters and O. Micke
Price
42.00 $
Volume 22 p. 311 - 315
Abstract
F. Bruns1, R. Mücke2, J. Büntzel3, K. Kisters4 and O. Micke5
1Abteilung Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover, 2Strahlentherapie Wiesbaden, St. Josefs-Hospital Wiesbaden, 3HNO-Klinik, Südharzkrankenhaus Nordhausen, 4Klinik für Innere Medizin I, St. Anna Hospital Herne, and 5Kl
Objective: The supplementation of trace elements as one method of complementary/alternative medicine (CAM) is becoming more important in the radiooncology. Actually, the internet is one of the main sources of information for CAM users but little is known regarding the quality of this kind of offered health information. Material and methods: To evaluate the quality of health information on the World Wide Web about the supplementation of trace elements in radiooncology, we performed an analysis of consumer websites in German for this topic after screening of all citations listed in the search engines “Fireball”, “AltaVista”, “Google”, “Yahoo”, and “Lycos”. Two reviewers, both experienced radiooncologists, independently analyzed this health information using the quality criteria and the scoring system of the Health Summit Working Group. Results: We found at maximum 522 web sites according to this topic, if the combination “trace element” and “cancer” and “radiotherapy” was used for search. The majority of the obtained web information was comprehensible and partly detailed, but frequently irrelevant. Only 4.4% of the analyzed web sites contained relevant statements concerning the supplementation of trace elements corresponding to scores 1 and 2 of the Health Summit Working Group scale. The observed inter-rater discrepancy was 4.3%. Conclusions: The majority of the information about the supplementation of trace elements in radiooncology, which can be found in the World Wide Web, was only of a poor quality. Therefore, qualified websites are needed to ensure an objective point of view for cancer patients with regard to the use of standard and experimental therapies of CAM for each tumor entity.Correspondence to:
Dr. F. Bruns
Department of Radiation Oncology
Hannover Medical School (MHH)
Carl-Neuberg-Straße 1
30625 Hannover, Germany
Email: [email protected]
Report
Trace Elements in Hessia Report of the 6th Workshop on Trace Elements and Electrolytes – AKTE 2/2004, Wiesbaden, Germany, November 13, 2004
R. Mücke, J. Büntzel, K. Kisters and O. Micke
Price
42.00 $
Volume 23 p. 0 - -1
Abstract
R. Mücke, J. Büntzel, K. Kisters and O. Micke
Letter to the Editor
Adiponectin, magnesium and arterial stiffness
K. Kisters, H. Liebscher, B. Gremmler and M. Hausberg
Price
42.00 $
Volume 23 p. 0 - -1
Abstract
K. Kisters, H. Liebscher, B. Gremmler and M. Hausberg
Letter to the Editor
Zinc and pyoderma gangrenosum
K. Kisters
Price
42.00 $
Volume 22 p. 0 - -1
Letter to the Editor
NTP-proBNP values in Black and Caucasian hypertensive patients
B. Gremmler, L. Ulbricht, M. Hausberg and K. Kisters
Price
42.00 $
Volume 22 p. 0 - -1
Abstract
B. Gremmler, L. Ulbricht, M. Hausberg and K. Kisters
Letter to the Editor
Fluvastatin therapy and endothelium-dependent brachial artery vasodilation and electrolytes in patients after kidney transplantation (a 3-years follow-up)
K. Kisters, M. Kosch, F. Tokmak and M. Hausberg
Price
42.00 $
Volume 20 p. 0 - -1
Abstract
K. Kisters, M. Kosch, F. Tokmak and M. Hausberg
Letter to the Editor
The role of electrolytes and NT-proBNP determination in cases of severe heart failure drug treatment
B. Gremmler, K. Kisters, C. Funke, H. Schleiting, M. Kunert and L.J. Ulbricht
Price
42.00 $
Volume 21 p. 0 - -1
Abstract
B. Gremmler, K. Kisters, C. Funke, H. Schleiting, M. Kunert and L.J. Ulbricht
