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Practical recommendations for the allergological risk assessment of the COVID-19 vaccination – a harmonized statement of allergy centers in Germany

Margitta Worm, Andrea Bauer, Bettina Wedi, Regina Treudler, Wolfgang Pfuetzner, Knut Brockow, Timo Buhl, Torsten Zuberbier, Joachim Fluhr, Gerda Wurpts, Ludger Klimek, Thilo Jakob, Hans F. Merk, Norbert Mülleneisen, Stefani Roeseler, Heinrich Dickel, Ulrike Raap, and Jörg Kleine-Tebbe

Volume 5 (2021) p. 72 - 76

Abstract

Allergologie select, Vol. 5/2021 (72-76)

Practical recommendations for the allergological risk assessment of the COVID-19 vaccination – a harmonized statement of allergy centers in Germany

Margitta Worm¹, Andrea Bauer², Bettina Wedi³, Regina Treudler⁴, Wolfgang Pfuetzner⁵, Knut Brockow⁶, Timo Buhl⁷, Torsten Zuberbier⁸, Joachim Fluhr⁸, Gerda Wurpts⁹, Ludger Klimek¹⁰, Thilo Jakob¹¹, Hans F. Merk¹², Norbert Mülleneisen¹³, Stefani Roeseler¹⁴, Heinrich Dickel¹⁵, Ulrike Raap¹⁶, and Jörg Kleine-Tebbe¹⁷

¹Allergology and Immunology, Department of Dermatology, Venereology and Allergology, Campus Charité Mitte, University Medicine Berlin, ²Clinic and Polyclinic for Dermatology, University Hospital Carl Gustav Carus at the Technical University Dresden, ³Department of Dermatology, Allergology and Venereology Comprehensive Allergy Center (CAC) Treatment Center for Hereditary Angioedema in the ZSE, Hannover Medical School, ⁴Clinic of Dermatology, Venereology and Allergology, Leipzig University Medical Center, ⁵Hesse Allergy Center, Clinic for Dermatology and Allergology, Marburg University Hospital, ⁶Dermatology Clinic Campus Biederstein, Klinikum rechts der Isar, Technical University of Munich, ⁷Dermatology Venereology and Allergology Clinic, University Medical Center Göttingen Georg-August-University, ⁸Department of Dermatology and Allergy, Comprehensive Allergy Center Charité – Universitätsmedizin Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, ⁹Department of Dermatology and Allergology, University Hospital Aachen, ¹⁰Center for Rhinology and Allergology of the ENT University Clinic Mannheim, Wiesbaden, ¹¹Department of Dermatology, Venerology and Allergology, University Hospital Giessen, ¹²Dermatology Clinic, RWTH Aachen University, ¹³Asthma and Allergy Center, Leverkusen, ¹⁴Allergy, Asthma and Anaphylaxis Center, Clinic of Pneumology, Allergology, Sleep and Respiratory Medicine, Augustinians Hospital, Cologne, ¹⁵Department of Allergology, Occupational and Environmental Dermatology, Clinic for Dermatology, Venereology and Allergology, St. Josef Hospital, Ruhr University Bochum, ¹⁶Department of Experimental Allergology and Immunodermatology, Department of Human Medicine, University of Oldenburg, and ¹⁷Allergy and Asthma Center Westend, Berlin, Germany
Severe allergic reactions to vaccines are very rare. Single severe reactions have occurred worldwide after vaccination with the new mRNA-based COVID-19 vaccines. PEG2000 is discussed as a possible trigger. We provide guidance on risk assessment regarding COVID-19 vaccination in patients with allergic diseases and suggest a standardized, resource-oriented diagnostic and therapeutic procedure. Reports of severe allergic reactions in the context of COVID-19 vaccination can be made via www.anaphylaxie.net using an online questionnaire.Correspondence to:
Univ.-Prof. Dr. med. Margitta Worm, Charité – Universitätsmedizin Berlin, Allergologie und Immunologie, Klinik für Dermatologie und Allergologie, Charitéplatz 1, 10117 Berlin
Email: [email protected]

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