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Predicting survival using the 2016 World Health Organization classification for anaplastic glioma

Je Beom Hong, Tae Hoon Roh, Sung Soo Ahn, Jung Youn Kim, Seok-Gu Kang, Jong Hee Chang, and Se Hoon Kim

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Volume 39 (2020) p. 188 - 195

Abstract

Clinical Neuropathology, Vol. 39 – No. 4/2020 (188-195)

Predicting survival using the 2016 World Health Organization classification for anaplastic glioma

Je Beom Hong¹#⁹, Tae Hoon Roh³, Sung Soo Ahn⁵, Jung Youn Kim², Seok-Gu Kang⁴#⁶#⁷, Jong Hee Chang⁴#⁶, and Se Hoon Kim⁶#⁸

¹Department of Neurosurgery, ²Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, ³Department of Neurosurgery, Ajou University Hospital, Ajou University School of Medicine, Suwon, ⁴Department of Neurosurgery, ⁵Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, ⁶Brain Tumor Center, Severance Hospital, Yonsei University Health System, ⁷Brain Research Institute, ⁸Department of Pathology, Yonsei University College of Medicine, and ⁹Graduate School, Yonsei University, Seoul, Republic of Korea
Aim: This study aimed to investigate the survival and prognostic factors for anaplastic glioma, and whether the updated 2016 WHO classification had superior ability to predict survival.
Materials and methods: Between January 2001 and December 2013, 113 consecutive patients were diagnosed with anaplastic glioma based on the 2007 WHO classification. We re-classified their diagnoses in accordance with the 2016 WHO classification. The Kaplan-Meier method, multivariate Cox proportional regression analysis, and a time-dependent receiver operating characteristic curve were used for the analysis.
Results: The median overall survival was 48.4 months among all patients, and 21.5 months for the anaplastic astrocytoma, IDH wild-type (AAw) group. The median progression-free survival was 31.8 months among all patients and 16.4 in the AAw group. Age, MGMT promoter methylation status, deep tumor location, and resection extent were associated with overall survival and progression-free survival.
Conclusion: We found that the 2016 WHO classification of central nervous system tumors had superior ability to predict survival in cases of anaplastic glioma, as compared to the 2007 WHO classification.Correspondence to:
Se Hoon Kim, MD, PhD
Department of Pathology
Yonsei University College of Medicine
50-1 Yonsei-ro, Seodaemun-gu,
Seoul 03722, Republic of Korea
Email: [email protected]

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