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Original Research

Prescription patterns of psychotropic medications and use of electroconvulsive therapy in Chinese patients with dementia

Lu Li, Zhi-Min Wang, Helen F.K. Chiu, Gabor S. Ungvari, Chee H. Ng, Ada W.Y. Tse, Grace K.I. Lok, Jian-Song Zhou, and Yu-Tao Xiang

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Volume 53 p. 722 - 727

Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 53 – No. 9/2015 (722-727)

Prescription patterns of psychotropic medications and use of electroconvulsive therapy in Chinese patients with dementia

Lu Li¹, Zhi-Min Wang², Helen F.K. Chiu³, Gabor S. Ungvari⁴,⁵, Chee H. Ng⁶, Ada W.Y. Tse³, Grace K.I. Lok⁷, Jian-Song Zhou⁸, and Yu-Tao Xiang¹,²

¹Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, ²Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, ³Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China, ⁴The University of Notre Dame Australia / Marian Center, ⁵School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, ⁶Department of Psychiatry, University of Melbourne, Melbourne, Australia, ⁷Kiang Wu Nursing College of Macau, Macao SRA, and ⁸Mental Health Institute of the Second Xiangya Hospital, Central South University, Hunan and Key Laboratory of Psychiatry and Mental Health of Hunan Province, China
Background: Little is known about psychiatric pharmacotherapy and somatic treatments in dementia in China. This study examined the prescription patterns of psychotropic medications and use of electroconvulsive therapy (ECT) in dementia patients hospitalized in a psychiatric institution in Beijing, China. Methods: This was a retrospective chart review of 401 patients with dementia treated over a period of 7 years (2007 – 2013) in a university-affiliated psychiatric institution in Beijing. Socio-demographic and clinical data were collected from the electronic chart management system (ECMS) for discharged patients. Results: Nearly all patients (96.8%) received psychotropic medications in order of frequency: second-generation antipsychotics (83.0%), benzodiazepines (77.8%), first generation antipsychotics (39.7%), antidepressants (29.7%), and mood stabilizers (24.7%). The rate of polypharmacy and ECT use was 82.0% and 3.7%, respectively. Prescription of mood stabilizers was associated with longer length of hospitalization. Conclusions: In a major psychiatric hospital in China, ECT was sporadically used in patients with dementia, while the vast majority of patients received at least one type of psychotropic medication. Factors contributing to the high use of psychopharmacological interventions in this population warrant further investigations.Correspondence to:
Dr. Zhi-Min Wang
Mood Disorders Center, Beijing Anding Hospital, China
or
Dr. Yu-Tao Xiang
3/F, Building E12, Faculty of Health Sciences
University of Macau, Avenida da Universidade
Taipa, Macau SAR, China
Email: [email protected] or [email protected]

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