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A patient with Sagliker syndrome who underwent parathyroidectomy: A case report and literature review

Jianping Ren, Xinyu Li, Baoyu Zhao, Deguang Wang, and Xuerong Wang

Volume 14 (2026) p. 30 - 38

Abstract

Clinical Nephrology – Case Studies, Vol. 14/2026 (30-38)

A patient with Sagliker syndrome who underwent parathyroidectomy: A case report and literature review

Jianping Ren, Xinyu Li, Baoyu Zhao, Deguang Wang, and Xuerong Wang

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Background: Sagliker syndrome (SS) is a rare yet severe complication of end-stage renal disease that is predominantly observed in patients who have undergone prolonged hemodialysis and develop secondary hyperparathyroidism (SHPT). SS is characterized by progressive craniofacial and maxillofacial bone deformities, such as mandibular widening, increased interdental spacing, and neuropsychiatric symptoms including anxiety, depression, and cognitive dysfunction. These manifestations significantly impair the quality of life of affected individuals. Case report: We report the case of a 42-year-old woman undergoing regular hemodialysis who was diagnosed with SHPT and SS. The patient was admitted to the hospital with a 3-year history of skeletal deformity. On December 29, 2012, she underwent total parathyroidectomy (PTx) with some parathyroid tissue transplanted to the left forearm. Over 12 years of regular follow-up, we found that clinical symptoms, such as facial deformity and bone pain, and laboratory indicators, including corrected serum calcium and phosphorus levels, significantly improved. Amazingly, the skull, which was altered in a “salt and pepper” pattern, improved significantly. Conclusion: After PTx in patients with SS, clinical symptoms and related laboratory indicators can be significantly improved, which is conducive to enhancing patient prognosis. Therefore, PTx should be performed in such patients as early as possible. However, further research is needed to develop a more standardized treatment plan for SS.Correspondence to:
Xuerong Wang, MD, Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Email: [email protected]

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