Volume 27, No. 4/2010(4th Quarter)
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Original
Competitive interaction of zinc and iron after venous and oral zinc administration in eutrophic children
M.F.R. Antunes, L.D. Leite, É.D.M. Rocha, N.J.N. Brito, M.C. França, C.A.B. Silva, M.G. Almeida, A.A. Rezende, J.S. Marchini and J. Brandão-Neto
Price
42.00 $
Page No. 185
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (185-191)
Competitive interaction of zinc and iron after venous and oral zinc administration in eutrophic children
M.F.R. Antunes1, L.D. Leite2, É.D.M. Rocha2, N.J.N. Brito3, M.C. França4, C.A.B. Silva1, M.G. Almeida3, A.A. Rezende3, J.S. Marchini5 and J. Brandão-Neto6
1Department of Nutrition, UNIFOR, 2Department of Nutrition, 3Department of Clinical Analyses, 4Department of Statistics, UFRN, 5Division of Clinical Nutrition, USP-FMRP and 6Department of Internal Medicine, UFRN, Natal/RN, Brazil
Objective: The aim of the present study was to evaluate the acute and chronic effects of zinc on the serum iron profile of 11 children aged 6 – 9 years. Methods: Body mass index was used to assess nutritional status. World Health Organization (WHO) Child Growth Standards (2007) were used to determine healthy weights. Venous (acute) and oral (chronic) zinc administration were carried out to investigate the serum iron profiles of the children. Results: All of the children had healthy weights, and energy, fat, fiber, calcium and iron consumption were below recommended levels. However, protein and carbohydrate levels were elevated. Protein and zinc increased significantly after the oral zinc administration. Chronic elevated zinc levels had a potentially inhibitory effect on the serum iron profile at the baseline level and during the venous zinc administration. The decrease in serum iron was not sufficient to promote anemia in any of the children studied. Conclusion: The potential inhibitory effect of a physiological or higher dose of zinc on serum iron was detected in normal-weight children aged 7 – 9 years. This negative effect of zinc did not affect hematocrit or hemoglobin levels.Correspondence to:
J. Brandão-Neto, MD, PhD
Department of Internal Medicine, CCS-UFRN
Av. Gal. Gustavo Cordeiro de Farias, s/n,
Petrópolis, CEP 59 010-180, Natal/RN, Brazil
Email: [email protected]
Original
Comparison of the hair metals in obese children according to slim therapy
R.W. Wójciak, E. Mojs and M. Stanislawska-Kubiak
Price
42.00 $
Page No. 192
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (192-195)
Comparison of the hair metals in obese children according to slim therapy
R.W. Wójciak1, 2, E. Mojs1 and M. Stanislawska-Kubiak1
1Department of Clinical Psychology, Poznan University of Medical Sciences and 2Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland
Aim: The aim of this preliminary study was to assess whether low calorie diets and physical activity therapy influence the concentration of calcium, magnesium, zinc, copper and iron in the hair of obese children. We evaluated the differences between the contents of biometals in the hair of obese children before therapy in comparison with trace elements in their hair after therapy. Method: The hair samples were taken from several points of occipital scalp before and after 6 weeks of slim procedure (–20% of recommend calories and not less than 4 h a day of physical activity). The content of metals was determined by flame-atomic absorption spectrometry method. Results: The levels of calcium, magnesium, zinc, and copper in the hair of obese children were significantly lower after therapy than before and were as follows: 634.3; 51.32; 166.9; 14.24; and 704.0; 56.14; 179.1; 14.51; µg/g; respectively. There were no differences in the hair iron contents (~17.0 µg/g). We also observed the significant differences between obese girls and boys in the level of hair calcium and copper. Conclusions: The type of slim procedure influenced the contents of metals in the hair of obese children. It may suggest that a physiological mechanism exists to keep trace elements in organism for the period of decreasing food intake. This preliminary study suggests that a more detailed examination and explanation is needed in this area.Correspondence to:
Dr. R.W. Wójciak
Department of Clinical Psychology
Poznan University of Medical Sciences
70 Bukowska Str.
60-812 Poznan, Poland
Email: [email protected]
Original
Influence of cadmium and zinc on the innate immune response in mice infected with Listeria monocytogenes
S. Simonyte and R. Planciuniene
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42.00 $
Page No. 196
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (196-201)
Influence of cadmium and zinc on the innate immune response in mice infected with Listeria monocytogenes
S. Simonyte1,2 and R. Planciuniene1
1Department of Microbiology, and 2Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
Objective: To study the effect of single and chronic cadmium exposure on mice innate response and antagonistic role of zinc after experimental infection with the intracellular pathogen, Listeria monocytogenes. Materials and methods: In the first experiment BALB/c mice were orally exposed to cadmium chloride and zinc sulphate solutions. After 8 weeks mice were injected intravenously with L. monocytogenes suspension. In the second experiment 24 h before the induction of infection mice were injected with cadmium chloride solution, which equals 0.5 LD50 and 0.05 LD50, respectively. The presence of the bacteria in mice organs was determined after 15 min, 3, 24 and 48 h of infection. Results: Long-term oral exposure to cadmium and zinc increased body weight of non-infected BALB/c mice. After long-term exposure to low doses of cadmium or cadmium with zinc the first clearance of listeria in the mice liver was the same. After 24 h there was a significant increase in number of bacteria in mice liver as compared to controls. Already 3 h past L. monocytogenes infection cadmium decreased elimination of bacteria from spleen. These results suggest that low doses of cadmium and long-term intoxication do not stimulate innate immunity and even can suppress early immune response. Single injection of cadmium (0.5 LD50) significantly decreased the number of bacteria in the mice liver and spleen 48 h after listerial infection, however, a small dose of cadmium (0.5 LD50) did not significantly differ from control. Conclusions: Single injection of cadmium high doses (0.5 LD50) enhanced the non-specific immunity of mice and speeded the elimination of bacteria from mice organs within 48 h after listerial infection. Long-term exposure to cadmium and zinc decreased non-specific resistance of mice to L. monocytogenes, because within 24 h after infection there was bacterial colonization in the mice liver. Zinc does not reduce the negative effect of cadmium on the mice innate immunity.Correspondence to:
Dr. S. Simonyte
Laboratory of Molecular Cardiology
Institute of Cardiology
Kaunas University of Medicine
Sukileliu 17, 50009 Kaunas, Lithuania
Email: [email protected]
Original
The propagation of excitation in portal vein smooth muscle – evidence for coupled “Hot Spots”
R. Patejdl and T. Noack
Price
42.00 $
Page No. 202
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (202-208)
The propagation of excitation in portal vein smooth muscle – evidence for coupled “Hot Spots”
R. Patejdl and T. Noack
Oscar Langendorff Institut für Physiologie der Universität Rostock, Rostock, Germany
Objective: Spontaneous excitation of rat portal vein (RPV) underlies rhythmic contractions. The spatial and temporal mode of excitation spread is largely unknown; experimental studies regarding this subject yielded conflicting results. Methods: Simultaneous measurements of spontaneous mechanical and electrical activity in a recording chamber with various electrode arrangements was used to measure and characterize the activity of isolated portal veins under in vitro conditions. Results: Electrical excitation occurs in a periodic, regular manner in RPV. When measured with short-distance-electrode arrangements, the duration of electrical complexes was in the range of 10 seconds. When distance was increased from 1 mm to 4 mm distance, 1.6 fold increases in amplitudes could be observed. The recorded voltage to force ratio showed no saturation. The data does neither fit to a type of signal propagation like in nerve tissue nor do they fit to a signal propagation like in cardiac tissue. Data fit to an excitation model of “distributed volcanoes”. Conclusions: Signal propagation in vascular smooth muscle is unlikely to be solely of electrotonic nature via gap junctions. Most favorable is a mechanism using distributed areas of excitation which must be interconnected and possess nearly simultaneous activation.Correspondence to:
Prof. Dr. T. Noack
Oscar Langendorff Institut für Physiologie der Universität Rostock
Gertrudenstr. 9, 18055 Rostock, Germany
Email: [email protected]
Original
The content of aluminum in the hair of Yorkshire terrier dogs from the Warsaw area depending on sex, age and keeping conditions
T. Kosla and E.M. Skibniewska
Price
42.00 $
Page No. 209
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (209-213)
The content of aluminum in the hair of Yorkshire terrier dogs from the Warsaw area depending on sex, age and keeping conditions
T. Kosla and E.M. Skibniewska
Department of Biology of Animal Environment, Faculty of Animal Sciences, Warsaw University of Life Sciences – SGGW, Warsaw, Poland
For many years, aluminum has been considered to be an element of little toxicity for humans which was a result of its low assimilation from alimentary tract, and quick removal through kidneys. Since the seventies of the 20th century aluminum was acknowledged as an element toxic for mammals, which cumulates in the organisms tissues. Aluminum compounds in living organism interfere with numerous essential metals, and metalloids may affect their biological availability. Some investigations also revealed the indispensability of the ultra trace doses of aluminum for poultry and goats. It was proved in the experiments performed by Yokel [25] that hair is a good indicator of aluminum content in the organism; similar conclusions were reached by Anke and Risch [6]. The present investigation aimed at determining the content of aluminum in the hair of the Yorkshire terrier breed of dogs from the Warsaw area, some of which were kept at home and some in the breeding kennels. Coat samples were collected from 76 Yorkshire terrier dogs. The differences in aluminum content in constantly growing dog hair (similar to human hair) were analyzed depending on sex, age and keeping conditions. Hair samples were degreased, then burned in the muffle furnace. Aluminum content was determined with the method of emission atomic spectrometry with plasma inductively induced (ICP-AES). The results are presented for the surface of air dried hair. The mean aluminum content in the hair of the investigated population amounted to 93.80 ± 72.81 mg·kg–1. No statistically significant differences were noted between the group of dogs from the breeding kennel and the group of dogs kept at home, however, a growing tendency of aluminum content was demonstrated depending on the kept dogs in the city environment. The data clearly shows a positive dependence of age and aluminum content in the hair, although no significant differences were observed depending on age and sex. Growing hair of Yorkshire terriers can be used for the determination of the content of metals in the dog organism and similarly as in the case of human hair as an indicator of the environmental contamination with aluminum.Correspondence to:
Prof. Dr. T. Kosla
Department of Biology of Animal Environment
Faculty of Animal Sciences
Warsaw University of Life Sciences, SGGW,
ul. Ciszewskiego 8
02-786 Warsaw, Poland
Email: [email protected]
Original
Assessment of fluoride exposure following application of toothpaste containing high concentration of fluoride
J. Opydo-Szymaczek and J. Opydo
Price
42.00 $
Page No. 214
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (214-219)
Assessment of fluoride exposure following application of toothpaste containing high concentration of fluoride
J. Opydo-Szymaczek1 and J. Opydo2
1Department of Pediatric Dentistry, Poznan University of Medical Sciences and 2Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Poznan, Poland
Objective: The aim of the study was to assess ingestion of fluorides following brushing with high fluoride toothpaste, as well as fluoride exposure associated with chronic use of the preparation. Material and methods: The subjects of the study were 15 adult volunteers. Fluoride concentrations were determined using ion-selective fluoride electrode (09-37 type) and a RAE 111 chloride-silver reference electrode (MARAT) in the mixture of saliva, distilled water and toothpaste remaining after procedures and recovered from the toothbrushes. The amounts of fluoride applied, recovered, and retained in the mouth were calculated for each treatment. Fluoride levels were also determined in urine samples of 9 subjects who used the toothpaste for two weeks. Results: Fluoride ingestion following application of high fluoride toothpaste ranged from 0.02 to 2.10 mg (mean 1.27 mg). There were statistically significant differences between fluoride levels in the baseline urine samples, samples collected after one week and after two weeks of tooth brushing (0.68 mg/l, 1.21 mg/l and 2.07 mg/l, respectively). Conclusion: Results indicate that high fluoride toothpaste is an essential source of fluoride intake. Since knowledge about fluoride ingestion following tooth brushing permits the clinician to recommend the safest schedule of fluoride treatment, it would be reasonable to include this information into the product leaflet.Correspondence to:
J. Opydo-Szymaczek
Department of Pediatric Dentistry
Poznan University of Medical Sciences
Bukowska 70
60-812 Poznan, Poland
Email: [email protected]
Original
Influence of age on selenium status in the course of selenium supplementation
J. Kvicala, V. Zamrazil, J. Nemecek and V. Jiranek
Price
42.00 $
Page No. 220
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (220-224)
Influence of age on selenium status in the course of selenium supplementation
J. Kvicala1, V. Zamrazil1, J. Nemecek1 and V. Jiranek2
1Institute of Endocrinology and 2DataPro, Prague, Czech Republic
100 µg of yeast-bound Se (SelenoPrecise, Pharma Nord, Denmark) was applied daily to the group of 30 seniors in the House for Seniors and to the group of 11 women working in the same House for Seniors in the region with low selenium status and intake in the course of 1.5 years. Selenium was analyzed in serum by neutron activation analysis and in urine (concentration, daily excretion, and ratio Se/creatinine) by fluorometry before and in the course of supplementation. Mean Se serum concentration of seniors was 58.5 ± 11.8 µg Se/l, mean Se serum concentration of adults was 68.9 ± 9.4 µg Se/l. Median of urine Se concentrations was 8.1 µg Se/l urine in the case of seniors and 8.8 µg Se/l urine of adults. Daily excretion 14.0 µg/day was detected for seniors and 16.7 µg Se/day for adults, and ratio Se (µg)/creatinine (mg) was 14.1 for seniors and 15.5 for adults. Detected concentrations demonstrated very low Se intake and very low Se status of inhabitants of the region. Blood and urine were obtained in the intervals of 13, 29, 97 days, 6, 12, and 18 months of supplementation and in the 40th and 67th day after its termination. Serum Se of both supplemented groups increased to the maximum during one year but, comparison of Se indices illustrated different homoeostatic metabolism of Se in adults and seniors by significantly different curves of all Se indices.Correspondence to:
J. Kvicala
Institute of Endocrinology
Národní 8
116 94 Prague 1, Czech Republic
Email: [email protected]
Original
Effects of boron administration on hepatic steatosis, hematological and biochemical profiles in obese rabbits
A. Basoglu, N. Baspinar, A. Sagkan Ozturk and P. Peker Akalin
Price
42.00 $
Page No. 225
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (225-231)
Effects of boron administration on hepatic steatosis, hematological and biochemical profiles in obese rabbits
A. Basoglu1, N. Baspinar2, A. Sagkan Ozturk3 and P. Peker Akalin2
1Department of Internal Medicine, Faculty of Veterinary Medicine Selcuk University, 2Department of Biochemistry, Faculty of Veterinary Medicine Selcuk University, Selcuklu Konya and 3Department of Internal Medicine, Faculty of Veterinary Medicine Mustafa Kemal University, Campus Hatay, Turkey
Objective: This study was designed to determinate the short and long term effects of boron at different doses on hematological and biochemical profiles, liver histology, and to evaluate boron efficacy on the pathogenic mechanisms leading to fatty liver. The aim of this study is to provide insight into boron metabolism. Material and methods: Boron was orally administrated in rabbits fed high energy diet at three different doses and 96 h, intervals for 7 months. Liver histology, and hematological, biochemical and ICP-AES analysis were performed. Results: Complete blood count and acid-base balance were not affected by short and long term boron administration. Decreases in hepatic fat infiltration and visceral fat amount in spite of body weight gain were considerable. The most pronounced findings were significant changes in hepatic TAG concentration and antioxidant status, and lipid profile. High boron doses have been tolerated at 96 h intervals. Conclusion: High boron doses can be tolerated for a long time at 96 h intervals. Boron seems to be effective on hepatic and visceral fat accumulation. This may be attributed to its effects of improving energy status, lowering oxidative stress and affecting lipid profile.Correspondence to:
Prof. Dr. A. Basoglu
Department of Internal Medicine
Faculty of Veterinary Medicine
Selcuk University, Campus
42070 Selcuklu Konya, Turkey
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
Selenium quantification and speciation in human spermatozoa: a description of present methods with a look at the future development
H. Bertelsmann, D. Behne, M. Hammadeh and A. Kyriakopoulos
Price
42.00 $
Page No. 232
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (232-234)
Selenium quantification and speciation in human spermatozoa: a description of present methods with a look at the future development
H. Bertelsmann1, D. Behne1, M. Hammadeh2 and A. Kyriakopoulos1
1Helmholtz-Zentrum Berlin für Materialien und Energie, Department of Elemental Analytics, Berlin and 2Universitätsklinikum des Saarlandes, Department of Gynaecology, Obstetrics and Reproductive Medicine, Homburg/Saar, Germany
Selenium in human spermatozoa is present in the form of two types of glutathione peroxidase 4 (GPx4), sperm nuclei glutathione peroxidase (snGPx) and phospholipid hydroperoxide glutathione peroxidase (PHGPx). The largest part of selenium in spermatozoa is bound to the latter form of GPx4 in many mammalian species. Among the methods applied for the selenium determination in whole sperm, instrumental neutron activation analysis (INAA) and electrothermal atomic absorption spectrometry (ETAAS) were routinely used with INAA being the reference application, as the selenium determination is independent from its chemical form, and weighing and drying is the only sample treatment necessary. In contrast to some other mammals, in which a truncated form of snGPx was found, snGPx is the only selenoprotein present in human sperm nuclei. For the quantitative determination of every selenoprotein present in spermatozoa in one experiment, improved approaches like the femtosecond laser ablation method coupled to mass spectrometry or long term irradiation in INAA, methods which can not only be applied directly on separated selenoproteins in gels after SDS-polyacrylamide electrophoresis but also can provide sufficient low limits of detection, are necessary.Correspondence to:
Dr. H. Bertelsmann
Helmholtz-Zentrum Berlin für Materialien und Energie
Department of Elemental Analytics
Glienickerstr.100
14109 Berlin, Germany
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
Selenium substitution during radiotherapy in head and neck cancer
J. Büntzel, O. Micke, M. Glatzel, U. Schäfer, D. Riesenbeck, K. Kisters, F. Bruns, K.G. Schönekaes, H. Dawczynski and R. Mücke
Price
42.00 $
Page No. 235
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (235-239)
Selenium substitution during radiotherapy in head and neck cancer
J. Büntzel1,8, O. Micke2,8, M. Glatzel3,8, U. Schäfer4,8, D. Riesenbeck5, K. Kisters6,8, F. Bruns7,8, K.G. Schönekaes8, H. Dawczynski9 and R. Mücke4,8
1Department of Otolaryngology, Head Neck Surgery, Südharz-Krankenhaus Nordhausen gGmbH, Nordhausen, 2Department of Radiotherapy, Franziskus-Hospital, Bielefeld, 3Department of Radiotherapy, Zentralklinikum Suhl GmbH, Suhl, 4Department of Radiotherapy, Klinikum Lippe-Lemgo, Lemgo, 5Department of Radiotherapy, Prosper-Hospital, Recklinghausen, 6Department of Internal Medicine I, St Anna Hospital, Herne, 7Department of Radiotherapy, Special Oncology, Medical School Hannover, Hannover, 8AKTE, The German Working Group “Trace Elements and Electrolytes in Oncology”, and 9Pharmaceutical company biosyn, Fellbach, Germany
Objective: The substitution of selenium effects in activation of the selenium dependent enzyme glutathione peroxidase which is important for scavenging free radicals. Until today only limited data was available about the clinical impact of selenium regarding the toxicities due to free radical producing therapies, e.g. irradiation or chemotherapy. Material and methods: 39 patients (8 female, 31 male) with advanced head neck cancer were included to a randomized Phase II study. The mean age was 63.52 ± 9.31 years. Tumor localizations: oral cancer 15 patients, oropharynx 19 patients, hypopharynx 5 patients, CUP 1 patient. Group A (n = 22) received 500 µg sodium selenite at the days of radiotherapy and 300 µg sodium selenite at holidays or weekend. Group B (17) was irradiated without any selenium substitution. Both groups were well balanced according age, gender, localization and stage of the tumor. We evaluated the RTOG grade of radiation-associated toxicities once per week. Results: We observed the following serious toxicities (Group A versus Group B): dysphagia 22.7% vs. 35.3%, loss of taste 22.7% vs. 47.1%, dry mouth 22.7% vs. 23.5%, and stomatitis 36.4% vs. 23.5%. A statistical trend (Fisher’s exact-test) is only seen in the area of loss of taste (p = 0,172). The analysis per week (Student t-test) had shown a significant reduction of dysphagia in the selenium group at the last week of irradiation. Conclusion: The small randomized trial has shown limited effects of selenium in the prevention of ageusia (loss of taste) and dysphagia due to radiotherapy because of head and neck cancer.Correspondence to:
PD Dr. med. J. Büntzel
Südharz-Krankenhaus Nordhausen GmbH
Dr.-Robert-Koch-Str. 39
99734 Nordhausen, Germany
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
Serum trace elements and brain atrophy in alcoholics
E. González-Reimers, C. Martín-González, L. Galindo-Martín, E. García-Valdecasas, I. Hernández-Betancor, C. Fernández-Rodríguez, P. Abreu-González and N. Fariña Gómez
Price
42.00 $
Page No. 240
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (240-245)
Serum trace elements and brain atrophy in alcoholics
E. González-Reimers1, C. Martín-González1, L. Galindo-Martín2, E. García-Valdecasas1, I. Hernández-Betancor1, C. Fernández-Rodríguez1, P. Abreu-González3 and N. Fariña Gómez2
1Servicio de Medicina Interna, Hospital Universitario de Canarias, La Laguna, 2Dpto de Química Analítica and 3Dpto. de Fisiología Universidad de La Laguna, Tenerife, Canary Islands, Spain
Alcoholics suffer several neurological problems, including alcoholic dementia, cerebellar atrophy, and thiamine deficiency related to Wernicke’s-Korsakoff encephalopathy. Cytokine-mediated neuroinflammation and oxidative damage may play a role in brain atrophy of uncomplicated alcoholics. Therefore, selenium and zinc deficiency, involved in antioxidative capacity, or iron excess, acting as a pro-oxidant, may all be involved. In this study on 61 alcoholic patients and 12 controls we found a more intense degree of atrophy in the former, differences affecting Huckmann (t = 2.95), bicauda (t = 3.93) and cella indices (t = 3.75) and cortical atrophy (t = 5.45, p < 0.001 in all cases). Differences were also observed between patients with cerebellar atrophy and those without, regarding copper (854 µg/l ± 181 µg/l vs. 1,088 µg/l ± 269 µg/l, p = 0.014), zinc (971 µg/l ± 696 µg/l vs. 1,817 µg/l ± 1,298 µg/l, p = 0.03), and serum ferritin, higher among patients with cerebellar atrophy (529 ± 370 ng/ml vs. 308 ± 209 ng/ml, p = 0.044). Serum ferritin showed a significant correlation with bicaudate index (rho = 0.3, p = 0.029) and Huckmann index (rho = 0.32, p = 0.02), and serum transferrin, an inverse one with Huckmann index (rho = –0.30, p = 0.031). However, selenium showed a direct, (opposite of what was expected) significant, correlation with the Huckmann index (rho = 0.35, p = 0.046). Thus, besides ferritin, higher among those with more intense atrophy, trace elements are only poorly related to brain atrophy, but patients with cerebellar atrophy do have lower serum copper and zinc levels.Correspondence to:
Dr. E. Gonzalez-Reimers
Dpto. De Medicina Interna
Hospital Universitario de Canarias
La Laguna, Tenerife, Canary Islands, Spain
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
Trace elements selenium and zinc as tumor markers in patients with advanced head and neck cancer
J. Büntzel, U. Knolle, A. Garayev, R. Mücke, U. Schäfer, K. Kisters, K.G. Schönekaes, R. Hunger, F. Bruns, M. Glatzel and O. Micke
Price
42.00 $
Page No. 246
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (246-249)
Trace elements selenium and zinc as tumor markers in patients with advanced head and neck cancer
J. Büntzel1,4, U. Knolle1, A. Garayev1, R. Mücke2,4, U. Schäfer2,4, K. Kisters3,4, K.G. Schönekaes4, R. Hunger4, F. Bruns4,5, M. Glatzel4,6 and O. Micke4,7
1Department of Otolaryngology, Head Neck Surgery, Südharz-Krankenhaus Nordhausen gGmbH, Nordhausen, 2Department of Radiotherapy, Klinikum Lippe-Lemgo, Lemgo, 3Department of Internal Medicine I, St Anna Hospital, Herne, 4AKTE – The German Working Group “Trace Elements and Electrolytes in Oncology”, 5Department of Radiotherapy, Special Oncology, Medical School Hannover, Hannover, 6Department of Radiotherapy, Zentralklinikum Suhl gGmbH, Suhl and 7Department of Radiotherapy, Franziskus-Hospital, Bielefeld, Germany
During the last few years we have collected data showing a relation between status of the disease and the serum concentrations of different trace elements. Are they able to monitor the disease as tumor markers? In a first study 100 untreated head and neck cancer patients were characterized by decreased levels of selenium, zinc and iron. Copper was the only increased. During the radiotherapy no changes of serum concentrations were seen. A further analysis had shown the differences between resectable and non-resectable tumors. As larger primary tumors were examined, the concentration of selenium in the serum of our patients decreased. These findings are supported by new data of NMR-tumor volumetry and trace elements concentrations in 21 patients. The relation between serum-selenium and tumor volume is stronger than between classical tumor markers (SCC; CEA, CYFRA 21-1) and the tumor volume. A last investigation has suggested that a destroyed homeostasis of trace elements is a sign of a pre-terminal ill patient. When the destroyed homeostasis is observed, the patient has a window of 4 – 6 weeks of remaining life time. Conclusions: Trace element status offers a lot of information about the course of the disease and the individual. But environmental factors have more impact on this trace element status than on other classical tumor markers.Correspondence to:
PD Dr. J. Büntzel
Südharz-Krankenhaus Nordhausen GmbH
Dr.-Robert-Koch-Str. 39
99734 Nordhausen, Germany
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
Selenium in oncology – an update
O. Micke, L. Schomburg, J. Buentzel, K. Kisters and R. Muecke
Price
42.00 $
Page No. 250
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (250-257)
Selenium in oncology – an update
O. Micke1, L. Schomburg2, J. Buentzel3, K. Kisters4 and R. Muecke5
1Department of Radiotherapy and Radiation Oncology, Franziskus Hospital, Bielefeld, 2Institute for Experimental Endocrinology, Charité Berlin, 3Department of Otolaryngology, Südharz Hospital Nordhausen, 4Department of Internal Medicine, St. Anna Hospital, Herne and 5Department of Radiotherapy, Lippe Hospital Lemgo, Germany (on behalf of the German Working Group Trace Elements and Electrolytes in Oncology (AKTE))
Selenium has been shown to possess cancer-preventive and cytoprotective activities in both animal models and human. Recent clinical trials showed the importance of selenium for clinical oncology. Our own clinical study involving 48 patients suggest that selenium has a positive effect on radiation-associated secondary lymphedema in patients with limb edemas as well as in the head and neck region, including endolaryngeal edema. Another randomized Phase III study of our group was performed to examine the cytoprotective properties of selenium in radiation oncology. From this study, for the first time, the significant benefit of selenium supplementation with regard to selenium deficiency and radiotherapy induced diarrhea has been shown in a prospective randomized trial. Survival data implies that supplementation with selenium does not interfere with radiation treatment. More recently there were emerging concerns coming up from two large clinical prevention trials, that selenium increases the possible risk of developing diabetes. Despite obvious flaws of both studies and good counterarguments, a controversial debate remains on the possible advantages and risks of selenium in cancer prevention. However, in light of the recent clinical trials the potential benefits of selenium supplementation in tumor patients are undeniable, although further research is needed.Correspondence to:
PD Dr. med. O. Micke
Klinik für Strahlentherapie und Radioonkologie
Franziskus Hospital
Kiskerstraße 26, 33615 Bielefeld, Germany
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
The effect of age and gender on the lithium content in rib bone of healthy humans
S. Zaichick, V. Zaichick, V. Karandashev, S. Ermidou-Pollet and S. Pollet
Price
42.00 $
Page No. 258
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (258-261)
The effect of age and gender on the lithium content in rib bone of healthy humans
S. Zaichick1, V. Zaichick2, V. Karandashev3, S. Ermidou-Pollet4 and S. Pollet4
1Northwestern University, Chicago, IL, USA, 2Medical Radiological Research Centre of Russian Academy of Medical Sciences, Obninsk, 3Institute of Microelectronics Technology and High Purity Materials, Chernogolovka, Russia, and 4University of Athens, Athens, Greece
Information on chemical elements of human bones and of their body burdens may be useful for assessing nutrition and for prevention and control of various disease states caused by mineral or trace element imbalance. Therefore, we studied the effect of age and gender on the lithium content in rib bone of healthy humans. Contents of Li in intact rib-bone of 80 relatively healthy 15 – 58 year old women (n = 38) and men (n = 42) were determined by inductively coupled plasma mass spectrometry. Mean values (M ± SEM) for the mass fraction of Li (milligram per kilogram of dry bone) in rib-bone of females, males, and females and males taken together were as follows: 0.0360 ± 0.0024, 0.0376 ± 0.0020, and 0.0369 ± 0.0015, respectively. No clear correlation was found between the Li content and age and gender. The results obtained may serve as indicative normal values for the lithium content in human rib-bone.Correspondence to:
V. Zaichick, DPhil, Cchem, FRSC
Medical Radiological Research Centre of RAMS
Obninsk, 249020 Russia
Email: [email protected]
Proceedings: 7th International Symposium on Trace Elements in Human: New Perspectives, October 13 – 15, 2009, Athens, Greece
Trace elements in health and diseases: cancer/inflammation
F. Atroshi, Th. Tallberg and T. Westermarck
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Page No. 262
Abstract
Trace Elements and Electrolytes, Vol. 27 – No. 4/2010 (262-264)
Trace elements in health and diseases: cancer/inflammation
F. Atroshi1, T. Tallberg2 and T. Westermarck3
1Pharmacology and Toxicology (ELTDK), University of Helsinki, Helsinki, 2The Helsinki Institute for Bio-Immunotherapy, Helsinki, and 3Rinnekoti Research Centre, Espoo, Finland
One of the main endeavors in cancer therapy is to prevent recurrent disease. Surgery and toxic treatment modalities have only invasively removed the symptoms of the etiological longstanding metabolic deficiency actually leading to cancer, but therapy has not tried to intervene with the etiology, and therefore the disease may recur. A healthy diet is perhaps the most important lifestyle change a person can make to help prevent diseases such as cardiovascular disease, diabetes and possibly cancer. Dietary supplements include vitamins, minerals, herbs or other botanicals, amino acids, and other substances intended to supplement the diet. By correcting the actual causative metabolic deficiency, recurrent disease can be postponed, the disease-free interval be prolonged and patients´ health preserved for decades. Good clinical results have been obtained with patients suffering from renal cell carcinoma, malignant melanoma, and prostate cancer. We use a specific ready-made product containing all the pertinent dietary supplementary natural factors needed to treat and possibly prevent recurrent disease in these different forms of cancer, as well as breast cancer. The treatment is so economical because the therapy includes only natural metabolic factors. This biological treatment is thus also in principle ethical. Furthermore bio-immunotherapy entails no side-effects.Correspondence to:
F. Atroshi, PhD
Pharmacology and Toxicology (ELTDK)
Koetilantie 7, 00014 University of Helsinki
P.O. Box 57, Helsinki, Finland
Email: [email protected]
