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Abstract

X. Cui¹, L.J. Liu², P. Liu¹ and J. Sun¹

¹Institute of Chemistry and Microbacteria Detection, College of Public Health, West Part of Shandong University, and ²Institute of Inorganic Chemistry, College of Pharmacy, West Part of Shandong University, Jinan, PR China
Absorption, distribution and elimination of both microcrystalline cisplatin and routine cisplatin in mice by oral administration were studied. Concentrations of cisplatin in blood, liver, stomach and kidney of mice were determined by graphite furnace atomic spectrophotometry. After oral administration of microcrystalline cisplatin, cisplatin could reach peak concentrations in stomach, blood, kidney and liver at about 30 min. The stomach had the highest cisplatin level of all determined tissues, and remained high (> 3.42 mg/g) within a duration of 1 h. Compared with the ordinary cisplatin drug, the microcrystalline cisplatin has a higher peak concentration, indicating that microcrystalline cisplatin can be absorbed effectively. Kidney had a higher peak concentration of cisplatin at approximately 45 min than both liver and blood, and the elimination rate remained slow for 4 h. Thus, microcrystalline cisplatin would be a potential orally taken anti-gastric carcinoma drug, but its kidney toxicity should not be neglected.

Abstract

P. Liu¹, S.D. Wu², X. Cui¹, Y.N. Yao¹, H.J. Dong¹, X.Y. Yuan¹ and Y. Liang³

¹Department of Chemistry and Microbacteria Detection, College of Public Health, Shandong University, ²Institute of Shandong Biological Medicine, and ³Shandong Qianfoshan Hospital Jinan, P.R. China
It has been proposed that aluminum is a contributing factor to several neurodegenerative disorders such as Alzheimer disease. To protect patients from the consequences of aluminum toxicity, aluminum-chelating agents have been introduced in clinical practice. This test is to determine the effect of oral 1,2-dimethyl-3-hydroxypyrid-4-one (deferiprone) on urinary copper, zinc and manganese level while it eliminates aluminum in Al-loaded rabbits. Thirty New Zealand white rabbits weighing 2.4 – 2.7 kg were treated with 600 mmol Al/kg/day (as the sulfate) 5 times weekly for 2 weeks by subcutaneous (s.c.) injection. Rabbits were randomly divided into 5 groups: control, DE1, DE2, DE3 and DE4. Two days after the last injection, the chelator test began. Three hours after the physiologic saline infusion and urine collection began, sterile water, deferiprone (500 mmol/kg), deferiprone (750 mmol/kg), deferiprone (1,000 mmol/kg), deferiprone (1,000 mmol/kg) + ascorbic acid (520 mmol/kg) were given intragastrically (i.g.), respectively, after 3 hours saline infusion. Urine was collected hourly for the next 6 h and analyzed for aluminum and essential elements copper, zinc and manganese using flame- or graphite furnace technique of atomic absorption spectrometry. Our results showed that deferiprone could highly increase aluminum output. Urinary excretion of copper, zinc and manganese was not affected by deferiprone administration. The co-administration of oral deferiprone with ascorbic acid did not cause a variety in urinary trace elements excretion.Correspondence to:
Prof. Liu Ping
Department of Chemistry and Microbacteria Detection
College of Public Health, West part of Shandong University
Jinan, Shandong, P.R. China 250012
Email: [email protected]

Abstract

X. Cui¹, J. Sun¹, X.Y. Ling², C.F. Zhao², Z.J. Liu¹ and G.F. Xu²

¹Institute of Chemistry and Bacteria Detection, College of Public Health, West Campus of Shandong University, and ²Institute of Food and Nutrition, College of Public Health, West Campus of Shandong University, Jinan, PR China
The zinc fractional absorption of Chinese children in the rural region in Shandong province was studied under the routine dietary model. The volunteers, aged 4.7 ~ 6.3 years, 5 males and 5 females, were recruited from Shandong rural region. Stable 67Zn was used as tracer to label ZnCl2, and Yb was used as a marker of 67Zn recovery. 67ZnCl2 solution and Yb were added to a biscuit, and then administered to volunteers orally. The food and feces samples of all subjects were collected for 12 consecutive days. AAS and TIMS were used for determination of total zinc and stable zinc isotope ratio in food and feces samples, and the zinc fractional absorption was calculated. The daily intakes of iron, protein, fat, ascorbic acid, phytic acid and fibre were determined by AAS or traditional chemical analysis method and compared with RNIs. Results: The results showed that the fractional absorption of zinc is 12.94 ± 3.32%, much lower than that reported in the West. The daily intake of zinc is 11.16 mg, that is 96.67% of RNI, and the intakes of protein and ascorbic acid are only 56.73 and 19.00% of RNIs, respectively. Conclusions: Under the dietary model of Shandong rural region, although the daily intake of zinc has been close to RNI, the children have low zinc fractional absorption. The low intakes of ascorbic acid and protein may play an important role in reducing the zinc availability.Correspondence to:
Prof. X. Cui
Institute of Chemistry and Bacteria Detection
College of Public Health
West Campus of Shandong University
Jinan 250012, China
Email: [email protected]

Abstract

X. Cui¹, J. Sun¹, X.Y. Ling², C.F. Zhao², Z.J. Liu¹ and G.F. Xu²

¹Institute of Chemistry and Bacteria Detection, ²Institute of Food and Nutrition, College of Public Health, West Campus of Shandong University, Jinan, PR China
Objective: The objective was to predict the bioavailability of iron in children aged 4- to 6- years from Chinese traditional diets consumed commonly in Shandong rural region on the basis of the contents of nutritional factors known to promote or inhibit food iron absorption. Materials and methods: Iron absorption measurement from Chinese traditional diets was made in 10 subjects by using iron-stable isotope 57Fe, as tracer to label FeSO4. 57Fe and Dy were added to a biscuit, and administered orally 3 times a day for 2 days. The diet and feces samples were collected for 10 consecutive days after the intake of 57Fe. Atomic absorption spectrophotometer (AAS) and thermal ionization mass spectrometers (TIMS) were used for the determination of iron, calcium and stable iron isotope. The daily intake of ascorbic acid, fat, phytic acid and fiber was determined by biochemical analysis. Results: The absorption of iron was 6.06 ± 2.24%, much lower than the 10% reported in the West, which was adopted by Chinese authority to revise Chinese Recommended Dietary Allowance (RDAs) in 1988. The daily intake of iron was 10.29 mg, which was 85.8% of Chinese “Reference Nutrient Intakes (RNIs)” in 1998. The intakes of protein and ascorbic acid were only 56.70 and 19.00% of RNIs, respectively. Conclusion: Under the actual dietary pattern of Shandong rural region, the iron uptake of children is low, due to poor iron absorption and the insufficient daily iron intake.Correspondence to:
Prof. X. Cui
Institute of Chemistry and Bacteria Detection
College of Public Health
West Campus of Shandong University
Jinan 250012, PR China
Email: [email protected]

Abstract

B.J. Wang¹, N. Liu², W. Hu², J. Fu², D.M. Guo², S.E. Wang² and X. Cui²

¹Institute of Clinical Pharmacology, Qilu Hospital, and ²Institute of Chemistry and Bacteria Detection, College of Public Health, West Campus of Shandong University, Jinan, China
The effects of ZnCl2 and Zn-EDTA on the development of psoriasis were studied in the model of vaginal epithelium and tail epidermis of mouse. The mitoses of vaginal epithelial cell in female mice of their estrogenic stage and the formation of granular cell layers in mice tail scale were observed. Methods: Mice were randomly divided into eight groups and treated with normal saline, methotrexate (MTX), ZnCl₂ and Zn-EDTA, respectively, for 10 days. To explore the influence of ZnCl₂ and Zn-EDTA on the excretion of Cu, Fe, Zn, Ca, Mg, Mn and Se, the concentration of those elements were analyzed by atomic absorption spectrometry. Results: The different doses of ZnCl₂ or Zn-EDTA could obviously inhibit the mitoses of vaginal epithelial cell (p < 0.05) and promote the formation of granular cell layers in mice tail scale (p < 0.05). No statistically significant results were found between the groups of ZnCl₂ and Zn-EDTA, and the group of methotrexate acted as the positive control. Conclusions: ZnCl₂ and Zn-EDTA are as effective as methotrexate on inhibiting hyperplasia of epidermal cells and increasing the formation of granular cell layers, possibly retarding the development of psoriasis.Correspondence to:
Prof. X. Cui
Institute of Chemistry and Bacteria Detection, College of Public Health, West Campus of Shandong University, Jinan 250012, PR China
Email: [email protected]

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