Original
Urinary KIM-1, IL-18 and Cys-c as early predictive biomarkers in gadolinium-based contrast-induced nephropathy in the elderly patients
Shao-Bin Duan, Gai-Ling Liu, Zhen-Qiu Yu and Peng Pan
Volume 80 (2013) p. 349 - 354
Abstract
Clinical Nephrology, Vol. 80 – No. 5/2013 (349-354)
Urinary KIM-1, IL-18 and Cys-c as early predictive biomarkers in gadolinium-based contrast-induced nephropathy in the elderly patients
Shao-Bin Duan, Gai-Ling Liu, Zhen-Qiu Yu and Peng Pan
Institute of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R.China
Background/Aims: This study was designed to investigate whether urinary kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18) and cystatin C (Cys-C) are early predictive biomarkers for gadolinium-based contrast-induced nephropathy (Gd-CIN) in the elderly patients undergoing gadolinium-enhanced magnetic resonance imaging (MRI). Methods: 60 elderly patients undergoing enhanced MRI using gadolinium-based contrast media were enrolled. Urine samples were collected before and 24 hours and 48 hours after the procedure, and KIM-1, IL-18 and Cys-C levels were measured by using an ELLSA kit respectively. Serum samples before and 24 hours and 48 hours after the procedure were also collected, and creatinine was measured by automatic biochemical analyzer. Results: Gd-CIN was diagnosed in 8 of 60 (13.3%) patients. At 24 hours after MRI with gadolinium administration in the Gd-CIN group, the urinary KIM-1, IL-18 and Cys-C were significantly increased. Logistic regression analysis showed that urinary KIM-1 and IL-18 at 24 hours after gadolinium injection were independent predictive markers of Gd-CIN. The predictable time of acute kidney injury (AKI) onset determined by urinary KIM-1, IL-18 and Cys-C was 24 hours earlier than by serum creatinine. Conclusions: Urinary KIM-1, IL-18 and Cys-C could be early predictive biomarkers of Gd-CIN in the elderly patients, which showed a good performance in early diagnosis of Gd-CIN as compared with serum creatinine.Correspondence to:
Shao-Bin Duan
Institute of Nephrology
The Second Xiangya Hospital
Central South University
Changsha 410011, Hunan, P.R. China
Email: [email protected]
Original
ERG is a novel and reliable marker for endothelial cells in central nervous system tumors
Matthew A. Haber, Amir Iranmahboob, Cheddhi Thomas, Mengling Liu, Amanda Najjar, and David Zagzag
Volume 34 p. 117 - 127
Abstract
Clinical Neuropathology, Vol. 34 – No. 3/2015 (117-127)
ERG is a novel and reliable marker for endothelial cells in central nervous system tumors
Matthew A. Haber1*, Amir Iranmahboob1*, Cheddhi Thomas2, Mengling Liu3, Amanda Najjar1, and David Zagzag1#2#4
1Microvascular and Molecular Neuro-Oncology Laboratory, 2Division of Neuropathology, 3Departments of Population Health and Environmental Medicine, and 4Department of Neurosurgery, NYU Langone Medical Center, New York, NY, USA
ETS-related gene (ERG) is a transcription factor that has been linked to angiogenesis. Very little research has been done to assess ERG expression in central nervous system (CNS) tumors. We evaluated 57 CNS tumors, including glioblastomas (GBMs) and hemangioblastomas (HBs), as well as two arteriovenous malformations and four samples of normal brain tissue with immunohistochemistry using a specific ERG rabbit monoclonal antibody. In addition, immunostains for CD31, CD34, and α-smooth muscle actin (α-SMA) were performed on all samples. CD31 demonstrated variable and sometimes weak immunoreactivity for endothelial cells. Furthermore, in 1 case of a GBM, CD34 stained not only endothelial cells, but also tumor cells. In contrast, we observed that ERG was only expressed in the nuclei of endothelial cells, for example, in the hyperplastic vascular complexes that comprise the glomeruloid microvascular proliferation seen in GBMs. Conversely, α-SMA immunoreactivity was identified in the abluminal cells of these hyperplastic vessels. Quantitative evaluation with automated methodology and custom Matlab 2008b software was used to calculate percent staining of ERG in each case. We observed significantly higher quantitative expression of ERG in HBs than in other CNS tumors. Our results show that ERG is a novel, reliable, and specific marker for endothelial cells within CNS tumors that can be used to better study the process of neovascularization.
*Both authors have equally contributed to this work.Correspondence to:
David Zagzag, MD, PhD
NYU Langone Medical Center, Department of Pathology
550 First Avenue, TH 441, New York, NY 10016, USA
Email: [email protected]
Original
Diagnostic indicators for adult-onset neuronal intranuclear inclusion disease
Yan Wang, Bo Wang, Lu Wang, Sheng Yao, Jing Zhao, Shanshan Zhong, Lu Cong, Ling Liu, Jiewen Zhang, Jun Zhang, and Daojun Hong
Price
42.00 $
Volume 39 (2020) p. 7 - 18
Abstract
Clinical Neuropathology, Vol. 39 – No. 1/2020 (7-18)
Diagnostic indicators for adult-onset neuronal intranuclear inclusion disease
Yan Wang1, Bo Wang2, Lu Wang3, Sheng Yao4, Jing Zhao5, Shanshan Zhong1, Lu Cong1, Ling Liu1, Jiewen Zhang5, Jun Zhang1, and Daojun Hong1
1Department of Neurology, Peking University People’s Hospital, Beijing, 2Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, 3Department of Neurology, Beijing China-Japan Friendship Hospital, 4Department of Neurology, The Sixth Medical Center of PLA General Hospital, Beijing, and 5Department of Neurology, The People’s Hospital of Henan Province, Zhengzhou, China
Adult-onset neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder. Abnormally high signals of diffusion-weighted image (DWI) along the corticomedullary junction are a useful diagnostic indicator for patients with adult-onset NIID. However, the DWI abnormalities usually were observed in the late stage of disease; further study might be helpful to elucidate some clinical indicators regarding the early awareness of NIID. In this study, we summarized 9 patients with NIID from multiple centers. The mean age was 60.0 ± 6.2 years. The mean duration of disease was 4.4 ± 3.2 years. The most common symptoms included cognitive impairment, episodic encephalopathy, and bladder dysfunction. Among the 6 patients with bladder dysfunction, 3 patients had the symptom prior to the development of other neurological symptoms; 5 patients needed permanent cystostomy. Isolated high DWI signals on the splenium of corpus callosum were observed in 2 patients at the early stage. The characteristic intranuclear inclusions in the skin were identified in all patients and confirmed by electron microscopy. Episodic encephalopathy or bladder dysfunction prior to other neurological symptoms were valuable diagnostic indicators for adult-onset NIID. High DWI signals on the splenium of corpus callosum might be an early indicator for the diagnosis of NIID. The immunostain of anti-ubiquitin or anti-p62 antibody was a convenient and sensitive biomarker for NIID with the background of typical phenotype with cognitive impairment and autonomic dysfunctions.Correspondence to:
Dr. Daojun Hong
Department of Neurology
Peking University People’s Hospital
#11 Xizhimen South Avenue,
Xicheng District, Beijing, 100044, China
Email: hongdaojun@
hotmail.com
Letter to the Editor
Allopurinol-induced acute kidney injury and DRESS syndrome without eosinophilia: A case report
Qianling Liu, Wenwen Hou, Yang Shen, and Sumei Zhao
Volume 96 (2021) p. 188 - 190
Abstract
Clinical Nephrology, Vol. 96 – No. 3/2021 – Letter to the editor
Allopurinol-induced acute kidney injury and DRESS syndrome without eosinophilia: A case report
Qianling Liu, Wenwen Hou, Yang Shen*, and Sumei Zhao*
Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*These authors contributed equally to this article.Correspondence to:
Yang Shen, MD
Department of Nephrology
Beijing Chaoyang Hospital, Capital Medical University
Beijing, China
Email: [email protected]
Original
Association between C-reactive protein and all-cause mortality among critically ill patients with acute kidney injury
Jingrong Qian, Lingling Liu, Fulu Chu, Yajuan Shen, Xiaohui Bai, Zhiming Lu, and Yong Wang
Volume 98 (2022) p. 123 - 134
Abstract
Clinical Nephrology, Vol. 98 – No. 3/2022 (123-134)
Association between C-reactive protein and all-cause mortality among critically ill patients with acute kidney injury
Jingrong Qian1, Lingling Liu2, Fulu Chu2, Yajuan Shen2, Xiaohui Bai2, Zhiming Lu2, and Yong Wang2
1Department of Clinical Laboratory, The Third Hospital of Shandong Province Affiliated to Shandong University, and 2Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
Aim: To explore the relationship between C-reactive protein (CRP) and mortality in critically ill patients with acute kidney injury (AKI).
Materials and methods: A total of 580 patients diagnosed with AKI within 48 hours of ICU admission between September 2017 and August 2019 were enrolled. Patients were followed for all-cause mortality in-hospital and then up to 2 years after discharge. We performed two multivariate regression analysis to assess the association between CRP and mortality, and conducted stratified analysis to assess whether the effect of the CRP differed across subgroups.
Results: According to initial CRP quartiles, patients were divided into 4 groups (quartile 1, CRP ≤ 2.87 mg/L; quartile 2, CRP: 2.87 – 25.95 mg/L; quartile 3, CRP: 25.95 – 111.51 mg/L; quartile 4, CRP > 111.51 mg/L). Patients with high CRP levels have higher APACHE-II score, longer length of stay in the ICU, and higher mortality. In multivariate regression analysis, high CRP was associated with the increased risk of in-hospital mortality after adjusting for age, gender, surgical grade, heart rate, serum potassium, serum chloride, coronary heart disease, and atherosclerotic cerebral infarction (quartile 4 vs. quartile 1, OR: 3.810, 95% CI: 2.081 – 6.973). For 2-year mortality, the increased trend was still significant with the OR (95% CI) of the quartile 4 group of 5.117 (2.678 – 9.780) after adjusting for confounders. Subgroup analyses detected in each group showed that the in-hospital and 2-year risk of mortality increased with higher CRP levels.
Conclusion: Higher CRP level was associated with the increased risk of mortality in critically ill patients with AKI.
Correspondence to:
Yong Wang
Department of Clinical Laboratory
Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan
Shandong 250021, China
Email: [email protected]
Letter to the Editor
A case of acute oxalate nephropathy after colonoscopy
Jianping Xiao, Dandan Li, Guiling Liu, and Deguang Wang
###ENGLISH_ABSTRACT_LINK###
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Volume 99 (2023) p. 206 - 208
Abstract
Clinical Nephrology, Vol. 99 – No. 4/2023 – Letter to the editor
A case of acute oxalate nephropathy after colonoscopy
Jianping Xiao, Dandan Li, Guiling Liu, and Deguang Wang
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Anhui, China
Correspondence to:
Deguang Wang
Department of Nephrology
The Second Affiliated Hospital of Anhui Medical University
678 Furong Road, Hefei, 230601, Anhui, China
Email: [email protected]
Original
Safety and efficacy of nirmatrelvir and ritonavir in kidney transplant recipients with COVID-19
Yadi Wang, Keqin Zhang, Ling Liu, Maozhi Tang, Ming Tang, Linguo Shen, Qiongyao Peng, Bangqin Hu, and Zhengsheng Rao
Volume 106 (2026) p. 96 - 109
Abstract
Clinical Nephrology, Vol. 106 – No. 2/2026 (96-109)
Safety and efficacy of nirmatrelvir and ritonavir in kidney transplant recipients with COVID-19
Yadi Wang1, Keqin Zhang1, Ling Liu1, Maozhi Tang1, Ming Tang1, Linguo Shen1, Qiongyao Peng1, Bangqin Hu2, and Zhengsheng Rao1
1The Center of Urology and Nephrology, and 2Department of Pharmacy, The Affiliated Hospital of Chongqing Medical University, Chongqing, China
Kidney transplant recipients (KTRs) are at an elevated risks for severe COVID-19 due to immunosuppression and comorbidities. This study retrospectively evaluated the safety and efficacy of nirmatrelvir-ritonavir (NR) in 42 KTRs with COVID-19, adjusting dosages based on estimated glomerular filtration rates. Over a 1-year follow-up, renal and hepatic functions, inflammatory markers, and acute respiratory distress syndrome (ARDS) incidence were monitored. Within the studied cohort, oxygen therapy was required in 64% of patients, with 19% necessitating mechanical ventilation; 21% developed ARDS. Multivariate analysis identified higher albumin levels (odds ratio (OR) = 0.696, 95% confidence interval (CI) 0.515 – 0.940) and CD4+ T-cell counts (OR = 0.982, 95% CI 0.968 – 0.998) as protective against ARDS, with an AUC of 0.859. Significant reductions in serum creatinine (p < 0.001) and aspartate aminotransferase (p = 0.01) were observed from admission to discharge, while alanine aminotransferase and estimated glomerular filtration rate (eGFR) remained stable. Complications were rare, occurring in only 2 patients. NR therapy demonstrated safety and effectiveness in KTRs, evidenced by improvements in renal and hepatic function as well as stable graft outcomes. CD4+ T-cell counts and albumin levels were identified as potential predictors of ARDS. These findings underscore the significance of early antiviral intervention and meticulous optimization of immunosuppressive management. However, further validation through larger multicenter prospective studies is necessary.Correspondence to:
Keqin Zhang, MD
The Second Affiliated Hospital of Chongqing Medical University
No. 74 Linjiang Road
Yuzhong District, Chongqing 400010, China
Email: [email protected]
