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Letters to the Editor

Resolution of pure red cell aplasia with continued production of low titer anti-epoetin antibodies

M.J. Leikis, I.K. Forbes, L.P. McMahon and G.J. Becker

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Volume 62 (2004) p. 481 - 482

Therapeutics

Ibuprofen sodium dihydrate, an ibuprofen formulation with improved absorption characteristics, provides faster and greater pain relief than ibuprofen acid

P. Schleier, A. Prochnau, A.M. Schmidt-Westhausen, H. Peters, J. Becker, T. Latz, J. Jackowski, E.U. Peters, G.E. Romanos, B. Zahn, J. Lüdemann, J. Maares and B. Petersen

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Volume 45 p. 89 - 97

Abstract

P. Schleier, A. Prochnau, A.M. Schmidt-Westhausen, H. Peters, J. Becker, T. Latz, J. Jackowski, E.U. Peters, G.E. Romanos, B. Zahn, J. Lüdemann, J. Maares and B. Petersen

¹Department of Maxillofacial Surgery/Plastic Surgery, Friedrich Schiller University, Jena, ²Department of Oral Surgery and Dental Radiology, Charité Universitätsmedizin Berlin, ³Department of Oral Surgery and Central Admittance, University Clinic of Düsseldorf, ⁴Department of Oral Surgery, School of Dental Medicine, University of Witten/Herdecke, ⁵Department of Oral Surgery and Implantology, University of Frankfurt am Main, Germany, ⁶Bayer Consumer Care AG, Basle, Switzerland, and ⁷Schlossweg ³, Grenzach-Wyhlen, Germany
Objective: The objective of this 6-hour study was to compare rate of pain relief, analgesic efficacy and tolerability of a novel ibuprofen formulation, ibuprofen sodium dihydrate, with that of ibuprofen acid in subjects with postoperative dental pain. Material and methods: The test formulation of ibuprofen sodium dihydrate (256 mg sodium salt) and the reference product both contain 200 mg ibuprofen. Subjects with moderate-to-severe pain after extraction of third molars were randomized to receive two tablets of either ibuprofen sodium dihydrate (198 subjects) or ibuprofen (198 subjects) in this double-blind, multicenter trial. Pain was measured using traditional descriptor scales and onset of analgesia assessed using the stopwatch method. Results: Median time to substantial pain relief occurred 14 minutes earlier in the ibuprofen sodium dihydrate group (p < 0.001). The first sign of pain relief, an increase in relief and time until the pain was half gone occurred significantly earlier and faster in the ibuprofen sodium dihydrate-treated patients (p < 0.02 – 0.00003). Corresponding numbers needed to treat were in the range 5 – 11. Reduction in pain intensity was evident within 5 minutes (p < 0.01) in the ibuprofen sodium dihydrate group compared to 15 minutes in the ibuprofen group. Pain intensity was reduced to half after 30 and 57 minutes in the ibuprofen sodium dihydrate and ibuprofen groups, respectively (p < 0.025). The overall analgesic efficacy in terms of summed pain intensity differences (SPID), total pain relief (TOTPAR) and remedication times in the two groups were similar. Both treatments were well tolerated and no serious events occurred. Conclusion: Ibuprofen sodium dihydrate provides faster and more efficacious pain relief during the first hour after intake when compared to a conventional ibuprofen acid formulation. The tolerability profiles are similar.Correspondence to:
B. Petersen; Bayer Consumer Care AG, Peter Merian-Straße 84, Postbox, 4002 Basel, Switzerland
Email: [email protected]

Originalarbeiten

27 Jahre akute Nierenersatztherapie an der Kinderdialyse Wien – Veränderungen in Epidemiologie und Outcome

27 years of acute renal replacement therapy at the Kinderdialyse Wien – changes in epidemiology and outcome

J. Becker, A. Vécsei, K. Dobrovits, D. Csaicsich, K. Arbeiter, T. Müller, E. Balzar und C. Aufricht

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Jahrgang 35 p. 483 - 489

Abstract

Nieren- und Hochdruckkrankheiten, Jahrgang 35, Nr. 11/2006, S. 483–489

27 Jahre akute Nierenersatztherapie an der Kinderdialyse Wien – Veränderungen in Epidemiologie und Outcome

J. Becker¹,², A. Vécsei¹,³, K. Dobrovits², D. Csaicsich², K. Arbeiter², T. Müller², E. Balzar² und C. Aufricht²

¹who contributed equally, ²Kinderdialyse Wien, Universitätsklinik für Kinder- und Jugendheilkunde, Wien, ³St. Anna Kinderspital, Wien
Der akute Nierenersatz gehört zu den kindernephrologischen Standardtherapien, wobei sich in den letzten Jahrzehnten die Rahmenbedingungen, zum Beispiel durch Etablierung der Kinder und Neugeborenenintensivpflege, deutlich geändert haben. Ziel dieser retrospektiven Studie war eine Übersicht über die Epidemiologie der akuten Nierenersatztherapie an der Kinderdialyse Wien seit der Inbetriebnahme 1978. In 27 Jahren wurden 219 Patienten (mittleres Alter 3,9 Jahre (0 – 19,5; 46% Mädchen, 54% Knaben) mit einer akuten Nierenersatztherapie behandelt. Die häufigste Diagnose war eine perinatale Grunderkrankung, danach folgten kardiologische Diagnosen und an dritter Stelle das hämolytisch urämische Syndrom (HUS). 120 Kinder erhielten eine Peritonealdialyse, 91 eine Hämodialyse und 8 Kinder beide Verfahren. Die Gesamtmortalität betrug 44,5%. Kinder an der Peritonealdialyse waren jünger, kleiner, leichter, wiesen einen niedrigeren BUN und einen niedrigeren Blutdruck bei Beginn der Nierenersatztherapie auf und litten signifikant häufiger an einer Mehrorganerkrankung. In den letzten 10 Jahren sank die Mortalität der an der Kinderdialyse behandelten Population aufgrund der autarken Betreuung der schwerstkranken Kinder auf den Intensivstationen. Als signifikante Prädiktoren für die Mortalität erwiesen sich in der Multivariatenanalyse das Neugeborenenalter und der Bedarf an Intensivpflege. Diese Daten bestätigen, dass vor allem die Patientencharakteristika und die Schwere der Grunderkrankung, nicht aber die Nierenersatztherapiemodalität das Überleben der betroffenen Kinder und Jugendlichen bestimmen. Da die Mehrzahl der akuten pädiatrischen Nierenersatztherapien aufgrund einer extrarenalen Grunderkrankung indiziert waren, spiegeln epidemiologische Arbeiten vor allem die Entwicklung des pädiatrischen Umfelds wider und sind somit nur äußerst bedingt zwischen verschiedenen Institutionen vergleichbar.Correspondence to:
Univ. Prof. Dr. med. C. Aufricht
Kinderdialyse Wien
Universitätsklinik für Kinder und Jugendliche
Währinger Gürtel 18-20
A-1090 Wien
Email: [email protected]

Original contribution

Incidental pituicytoma after accidental head trauma – case report and review of literature

A. Grote, A. Kovacs, H. Clusmann, A.J. Becker and P. Niehusmann

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Volume 29 p. 127 - 133

Abstract

Clinical Neuropathology, Vol. 29 – No. 3/2010 (127-133)

Incidental pituicytoma after accidental head trauma – case report and review of literature

A. Grote¹, A. Kovacs², H. Clusmann¹, A.J. Becker³ and P. Niehusmann³

Departments of ¹Neurosurgery, ²Radiology/FU Neuroradiology, and ³Neuropathology, University of Bonn Medical Center, Bonn, Germany
Objective: We report on a patient with pituicytoma, i.e. a rare neoplasm of the neurohypophysis, with unusual anamnestic manifestation. Case material: After a car accident, the patient suffered from severe persisting headaches. Diagnostic procedures revealed a minor visual impairment and restriction of the gonado- and somatotropic pituitary axis. MRI showed an architecturally solid, well demarcated and homogenous suprasellar lesion. Due to the challenging location of the lesion with a small intrasellar mass and larger suprasellar part within the hypophyseal stalk, a subtotal resection was carried out to save the pituitary function and for neuropathological assessment comprising numerous stainings and immunohistochemical reactions. We observed a highly differentiated, low proliferative, rather cellular and in individual parts moderately pleomorphic tumor with cells arranged in storiform or whorled patterns, that strongly expressed S-100 protein, microtubulus-associated protein 2 (MAP2) and vimentin. Postoperative visual field testing was inconspicuous, but pituitary malfunction was persistent. With respect to the accidental discovery of this pituicytoma, it remains unresolved whether the persisting headache was due solely to the head trauma or was additive with the effects of the pituicytoma. Conclusion: To date less than 30 bona fide examples have been described and typically present symptoms due to mass effects such as visual disturbances, hypopituitarism as well as interference with hypothalamic dopamine release, resulting in subsequent hyperprolactinemia accompanied by decreased libido and amenorrhea in females. These neoplasms represent an important differential diagnosis with respect to suprasellar lesions and a clinical and neuropathological challenge.Correspondence to:
A. Grote, MD
Clinic of Neurosurgery
University of Bonn
Medical Center
Sigmund-Freud-Str. 25
53105 Bonn, Germany
Email: [email protected]

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