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Original Research

Research on radiotherapy at different times of the day for inoperable cervical cancer

Li Chang, Lan Li, Wenhui Li, Meiping Jiang, Yunhe Jv, Li Wang, Yu Hou, Qing Long, and Shuhui Yu

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Volume 54 p. 856 - 864

Abstract

International Journal of Clinical Pharmacology and Therapeutics, Vol. 54 – No. 11/2016 (856-863)

Research on radiotherapy at different times of the day for inoperable cervical cancer

Li Chang*, Lan Li*, Wenhui Li, Meiping Jiang, Yunhe Jv, Li Wang, Yu Hou, Qing Long, and Shuhui Yu

Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University, Cancer Hospital of Yunnan Province, Kunming, China
Purpose: To investigate the radiation effects and acute damage in inoperable cervical cancer patients irradiated at different times as well as the underlying mechanisms. Methods: 67 patients were randomized to a morning group (MG, 9:00 – 11:00 AM) and an evening group (EG, 9:00 – 11:00 PM) and both received external beam radiotherapy (RT) (50 Gy in 25 fractions) at different times. Brachytherapy (36 – 42 Gy in 6 – 7 fractions) was also performed to enhance the radiation response twice every week in all patients at the same time. Clinical therapeutic effects and acute toxicities were evaluated after RT. Flow cytometry was analyzed before and after RT. Results: Patients’ response to radiation was similar in the two groups. Incidences of overall and high-grade (III – IV) diarrhea in the MG vs. the EG were 75.0% vs. 57.6% and 12.5% vs. 6.1%, respectively. The incidence of severe hematological toxicity in the EG was significantly increased compared to the MG group. Cell apoptosis in the EG was significantly higher at 9:00 – 11:00 PM than that at 9:00 – 11:00 AM after RT. No significant differences were found in Gap Phase 0/Gap Phase 1 (G0/G1), Gap Phase 2/Metaphase Phase (G2/M), and Synthesis Phase (S) phase between different times and groups, nor were expressions of Per1, Per2, and Clock. But expressions of Per1, Per2, and Clock were significantly negative with G2/M phase and positively correlated with cell apoptosis. Conclusion: RT at different time intervals results in similar efficacy. However, RT in the morning reduces severe hematological toxicity. Radiation responses may be associated with circadian genes by influence of cell cycles and apoptosis. 

*These authors contributed equally to this work.Correspondence to:
Wenhui Li, MD, PhD
Department of Radiation Oncology
The Third Affiliated Hospital of Kunming Medical
University
Cancer Hospital of Yunnan Province
No.519 Kunzhou Road, Kunming 650118, China
Email: liwenhui64_25@ 126.com.

Original

WT1 mutation-associated nephropathy: a single-center experience 

Zhihui Yue, Haiyan Wang, Hongrong Lin, Juan Yang, Ting Liu, Yulin Liu, Huamu Chen, Liangzhong Sun

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Volume 87 (2017) p. 245 - 254

Abstract

Clinical Nephrology, Vol. 87 – No. 5/2017 (245-254)

WT1 mutation-associated nephropathy: a single-center experience 

Zhihui Yue¹*, Haiyan Wang²*, Hongrong Lin¹, Juan Yang³, Ting Liu¹, Yulin Liu⁴, Huamu Chen¹, Liangzhong Sun¹

¹Children’s Kidney Disease Center, Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ²Department of Pediatrics,  Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou,  ³Department of Pediatrics, Liaocheng People’s Hospital, Shandong, and ⁴Department of Pediatrics, Boai Hospital, Zhongshan, Guangdong Province, China
This study explored Wilms’ tumor 1 (WT1) mutations in children with, or suspected of having, steroid-resistant nephrotic syndrome (SRNS), referred to or treated in our hospital in the past 6 years as well as the correlation between genotype and phenotype in WT1 mutation-associated nephropathy in Chinese patients. In total, 76 patients participated in the study. WT1 mutations were identified in 15 patients, 5 of whom harbored splice-site mutations in intron 9. Four of these 5 patients exhibited early onset of nephropathy and rapid deterioration of renal function. Missense mutations were detected in 8 patients, 4 of whom harbored hot-site mutations and had early-onset proteinuria. Of these 4 patients, rapid progression to end-stage renal disease was only observed in 1. Nonsense mutations were identified in 2 patients; both had a large number of immature glomeruli in the kidney cortex. Calcineurin inhibitors (CNI) were administered in 8 patients. Two patients with missense mutations and 1 patient with a nonsense mutation achieved complete remission. Two patients with missense mutations and 2 with splice-site mutations showed an improvement. One patient with a splice-site mutation showed no changes. In conclusion, a high WT1 mutation rate was observed in this group of SRNS patients. Patients with splice-site mutations experienced a rapid disease progression, and patients harboring nonsense mutations showed a prominent glomerular developmental delay. CNI therapy was effective in patients with WT1 missense mutations and nonsense mutations. 

*These two authors contributed equally.Correspondence to:
Professor Liangzhong Sun, MD, PhD 
Department of Pediatrics, The First Affiliated Hospital
Sun Yat-Sen University
No. 58, Zhongshan Road II, Guangzhou 510080, China
Email:  sunlzh@ mail.sysu.edu.cn

Neph rology Education

Fibronectin glomerulopathy caused by genetic FN1 mutation: A case report and literature review 

Bairu Shi, Yang Xia, Kejia Li, Long Jin, Xian Sun, and Hui Yu

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Volume 105 (2026) p. 352 - 359

Abstract

Clinical Nephrology, Vol. 105 – No. 5/2026 (352-359)

Fibronectin glomerulopathy caused by genetic FN1 mutation: A case report and literature review 

Bairu Shi¹#², Yang Xia¹#², Kejia Li¹#², Long Jin¹#², Xian Sun¹#², and Hui Yu³#⁴

¹Department of Nephrology, The First People’s Hospital of Jiashan, Jiaxing City, Zhejiang Province, ²Department of Nephrology, Jiashan Branch of the Second Affiliated Hospital of Medical College Zhejiang University, Jiaxing, ³Department of Orthopedics Surgery, The First People’s Hospital of Jiashan, Jiaxing City, Zhejiang Province, and ⁴Department of Orthopedics Surgery, Jiashan Branch of the Second Affiliated Hospital of Medical College Zhejiang University, Jiaxing, China
Background: Fibronectin glomerulopathy (FGP), also known as fibronectin deposition glomerulopathy (GFND), is a rare hereditary autosomal dominant glomerular disease. Its clinical manifestations are proteinuria, hematuria, hypertension, and hyperkalemic distal renal tubular acidosis, which often progresses slowly to end-stage renal disease.
Case description: We report a 21-year-old woman with fibronectin glomerulopathy who underwent renal puncture at the age of 10. The pathology was considered to be thrombotic microangiopathy, and it was not treated regularly. This time, renal puncture was performed again due to proteinuria combined with elevated serum creatinine. Light microscopy showed severe mesangial matrix hyperplasia of glomeruli with dense deposition and foam cell aggregation in capillary loops. Fibrinogen immunostaining was positive. Electron microscope showed severe hyperplasia of mesangial matrix, and a large amount of electron-dense matter deposited in mesangial area. Perfect genetic testing suggested that the FN1 gene was heterozygous for NM_212482.4 (c.2918A>G), that is, Y973C mutation. Therefore, she was diagnosed with fibronectin glomerulopathy and was given sacubitril valsartan sodium tablets 200 mg b.i.d. orally.
Conclusion: We report a case of a patient with fibronectin glomerulopathy and review the literature of this disease. The disease often has insidious onset, and fibronectin deposition is a typical pathological change that can result. The disease slowly progresses to end-stage renal disease. At present, there is no specific treatment. It is advocated to use reninangiotensin-aldosterone system blockers to strictly control blood pressure and proteinuria, and the overall prognosis is poor. Genetic testing techniques may be helpful in early diagnosis of the disease.Correspondence to:
Dr. Hui Yu
Department of Orthopedics Surgery
The First People’s Hospital of Jiashan
or
Department of Orthopedics Surgery
Jiashan Branch of the Second Affiliated
Hospital of Medical College Zhejiang University
1218 South Sports Road
Jiaxing City, PR China
Email: [email protected]

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