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Books: 0	Journals: 2	Articles: 4

Abstract

Clinical Nephrology, Vol. 77 – No. 1/2012 (79-84)

Tacrolimus-induced thrombotic microangiopathy: natural history of a severe, acute vasculopathy

John M. Carson¹, Eric D. Newman¹, John L. Farber³ and Edward J. Filippone²

¹Department of Medicine, ²Division of Nephrology of the Department of Medicine, and ³Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA , USA
Calcineurin inhibitors (CNI) have been clearly associated with posttransplant thrombotic microangiopathy (PTTMA). We report a case of de novo PT-TMA involving predominantly small arteries and arterioles of a renal allograft in a patient receiving tacrolimus. Serial biopsies demonstrate the natural history of this lesion through the chronic nonspecific phase. The case is discussed in the context of a literature review of PT-TMA in general and CNI use in particular.Correspondence to:
Edward J. Filippone, MD, FACP228 S. Broad St,
Philadelphia, PA 19145, USA
Email: [email protected]

Abstract

Clinical Nephrology, Vol. 79 – No. 2/2013 (143-153)

Immunosuppressive treatment of idiopathic membranous nephropathy: the dilemma continues

Edward J. Filippone

Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Here you get the table 1 and the supplement as pdf for free.Correspondence to:
Edward J. Filippone, MD,
Clinical Associate Professor of Medicine
Division of Nephrology, Department of Medicine
Thomas Jefferson University
2228 South Broad St, Philadelphia, PA, 19145, USA
Email: [email protected]

Abstract

Clinical Nephrology, Vol. 82 – No. 1/2014 (7-15)

Idiopathic membranous nephropathy and IgG4: an interesting relationship

Edward J. Filippone

Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Idiopathic membranous nephropathy (iMN) is a single-organ autoimmune disease characterized by subepithelial deposition of immune complexes containing IgG4 resulting in proteinuria, nephrotic syndrome, and, in some, end-stage renal disease. The pathogenesis involves a chronic IgG4 response against specific podocyte antigens which have now been at least partially defined in the neonatal, early childhood, and adult varieties. More has recently been learned about the genetic predisposition as well. This review discusses the pathophysiology of iMN in light of these discoveries and what is known about the genesis and potential clinical ramifications of an antigenspecific IgG4 response.Correspondence to:
Edward J. Filippone, MD FACP
Division of Nephrology, Department of Medicine
Thomas Jefferson University
2228 South Broad St. Philadelphia, PA 19145, USA
Email: [email protected]

Abstract

Clinical Nephrology – Case Studies, Vol. 14/2026 (24-29)

Late-onset recurrent lupus nephritis in a kidney transplant recipient

Jessica K. Cobb², Paul Endres², Prashamsa Shenoy¹, Edward J. Filippone¹, Maitreyee Gupta¹, and Rakesh Gulati¹

¹Department of Transplant Nephrology, and ²Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Long-term kidney allograft survival continues to be a challenge, despite improvements in the short term. Recurrence of glomerular disease is a significant cause of allograft failure. We report a case of graft dysfunction 27 years post transplant attributed to biopsy-proven recurrent class IV lupus nephritis. Following targeted medication adjustments aimed at treating lupus nephritis, the patient achieved complete remission within 6 months, which has been sustained for 4 years. Although recurrent lupus nephritis is reported to occur up to 16 years after transplantation, it is uncommon, and represents a potentially treatable cause of graft failure. This report underscores the critical need for heightened awareness and prompt management of recurrent lupus nephritis regardless of the time post transplant to enhance long-term allograft survival. Furthermore, our case highlights that positive allograft staining in peritubular capillaries for C4d may result from recurrent immunecomplex disease as opposed to antibodymediated rejection.Correspondence to:
Dr. Jessica Cobb, 1199 Ludlow St. #1401, Philadelphia, PA 19107, USA
Email: [email protected]

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