Dustri Online Services

Search Results

Books: 0	Journals: 1	Articles: 2

Nephrology Education

Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity? 

Kensei Yahata, Yuko Kikuchi, Mitsuteru Koizumi, Koichi Seta, Hideki Wakui, Atsushi Komatsuda, and Akira Shimizu

Price
42.00 $

Price

42.00 $

Add to Cart ###ENGLISH_ABSTRACT_LINK### ###FREE_ENGLISH_ARTICLE_DOWNLIAD_LINK###

Volume 89 (2018) p. 123 - 129

Abstract

Clinical Nephrology, Vol. 89 – No. 2/2018 (123-129)

Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity? 

Kensei Yahata¹, Yuko Kikuchi¹, Mitsuteru Koizumi¹, Koichi Seta¹, Hideki Wakui², Atsushi Komatsuda³, and Akira Shimizu⁴ 

¹Department of Nephrology, National Hospital Organization Kyoto Medical Center, Kyoto, ²Department of Life Science, Akita University Graduate School of Engineering Science, Akita, ³Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, and ⁴Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan
A 71-year-old male with a past history of lower limb arteriosclerosis obliterans developed nephrotic syndrome and renal dysfunction. Renal biopsy showed diffuse global endocapillary proliferative lesions with infiltration of mononuclear cells and occasional foam cells. An irregular double contour of the glomerular basement membrane and global mild-to-moderate mesangial proliferative lesions were observed, indicating membranoproliferative glomerulonephritis. Congo red staining was negative. Routine immunofluorescence studies showed no obvious immunoglobulin or complement depositions. Electron microscopy showed endocapillary proliferative lesions and infiltration of macrophages with abundant lysosomes. Irregular subepithelial, subendothelial, and mesangial electron-dense deposits were observed in glomeruli. In these electron-dense deposits, parallel arrangement striated structures were detected. All known disease entities with Congo red-negative and immunoglobulin-negative glomerular deposits were pathologically excluded. The glomerular lesion in our case might be a new disease entity. Correspondence to:
Kensei Yahata, MD
 Department of Nephrology
National Hospital Organization Kyoto Medical Center
1-1 Fukakusa Mukaihata-cho, Fushimi-ku,
Kyoto 612-8555, Japan 
Email: kenseiyahata@ yahoo.co.jp

Nephrology Education

Monoclonal immunoglobulin G1 κ-type atypical antiglomerular basement membrane disease accompanied by necrotizing glomerulonephritis 

Takayuki Tsuji, Naro Ohashi, Taichi Sato, Daiki Goto, Soichiro Nagata, Takashi Matsuyama, Yoshitaka Naito, Naoko Tsuji, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Yoshihide Fujigaki, Akira Shimizu, and Hideo Yasuda

Price
42.00 $

Price

42.00 $

Add to Cart ###ENGLISH_ABSTRACT_LINK### ###FREE_ENGLISH_ARTICLE_DOWNLIAD_LINK###

Volume 93 (2020) p. 152 - 157

Abstract

Clinical Nephrology, Vol. 93 – No. 3/2020 (152-157)

Monoclonal immunoglobulin G1 κ-type atypical antiglomerular basement membrane disease accompanied by necrotizing glomerulonephritis 

Takayuki Tsuji¹, Naro Ohashi¹, Taichi Sato¹, Daiki Goto¹, Soichiro Nagata¹, Takashi Matsuyama¹, Yoshitaka Naito¹, Naoko Tsuji¹, Shinsuke Isobe¹, Tomoyuki Fujikura¹, Akihiko Kato², Yoshihide Fujigaki³, Akira Shimizu⁴, and Hideo Yasuda¹

¹Internal Medicine ¹, ²Blood Purification Unit, Hamamatsu University School of Medicine, Shizuoka, ³Department of Internal Medicine, Teikyo University School of Medicine, and ⁴Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
Introduction: Patients without detectable serum antiglomerular basement membrane (GBM) antibodies but with GBM staining for immunoglobulins (Ig), absence of a crescentic phenotype, mild renal insufficiency, and absence of pulmonary hemorrhage have atypical anti-GBM diseases. We report the case of a 64-year-old man with slowly progressive glomerulonephritis.
Case history: A 64-year-old Peruvian man presented with persistent microscopic hematuria, proteinuria of 2.1 g/g creatinine (Cr), serum Cr 1.00 mg/dL, and C-reactive protein 0.80 mg/dL. Renal biopsy revealed necrotizing glomerulonephritis with 39% cellular crescent formation and diffuse segmental endocapillary proliferation. He had linear staining of monoclonal IgG1-κ in the capillary walls but no detectable serum anti-GBM antibodies. Because renal dysfunction was slowly progressing, steroid monotherapy was initiated, and serum Cr level decreased from 1.48 to 1.13 mg/dL. However, serum Cr increased again to 1.35 mg/dL owing to active glomerular damage with crescent formation and endocapillary proliferation, confirmed by the second renal biopsy at 9 months after therapy. Renal function improved after cyclophosphamide therapy.
Conclusion: We described an atypical variant of anti-GBM disease due to monoclonal IgG1-κ. Unlike usual atypical anti-GBM disease cases, we observed crescent formation in our patient. Further investigations are needed to identify the cause of nondetectable serum anti-GBM antibodies and to describe the causal relationships between clinicopathological features and the pattern of IgG subclass and light chain in atypical anti-GBM disease.Correspondence to:
 Takayuki Tsuji, MD, PhD
Internal Medicine 1, Division of Nephrology
Hamamatsu University School of Medicine
1-20-1 Handayama, Higashi-ku,
Hamamatsu, Shizuoka 431-3192, Japan
Email: [email protected]

Warenkorb Übersicht

Warenkorb Übersicht
Typ	Anz	Rabatt	MwSt	Preis
Der Warenkorb ist leer

Ihr Warenkorb

Search Results

Warenkorb Übersicht

Senden Sie uns eine E-Mail