Abstrakt

Background: Kounis syndrome is a rare type of allergic or hypersensitivity-induced acute coronary syndrome. The release of numerous inflammatory mediators induces vasospasms and potential thrombosis leading to myocardial infarction.
Case History: We present the case of a 65-year-old woman with metastatic melanoma who experienced chest tightness and dyspnoea after her third infliximab infusion, which presented transitory ST-elevations. Suspecting allergic reactions and acute coronary syndrome she was simultaneously treated for both conditions with complete resolution of symptoms and electrocardiographic alternations without the need for further percutaneous coronary intervention.
Conclusion: This case highlights the importance of considering Kounis syndrome as a potentially life-threatening complication during monoclonal antibody infusion, even in the absence of a prior allergic history and typical skin manifestations. Early recognition and treatment are crucial and spared our patient further invasive diagnostical and therapeutical interventions.

*Diese beiden Autorinnen haben gleichermaßen zu dieser Arbeit beigetragen.

Erstpublikation in Allergologie select, mit freundlicher Genehmigung der Autoren





Seeli C, Patriki D, Ali OH, Blumenröther A-K, Brüggen M-C, Nolting A, Guillet C. Potential infliximab-induced Kounis syndrome in a patient with metastatic melanoma. Allergol Select. 2026; 10: 11-15.
DOI 10.5414/ALX02612E

Autoreninformation

Autoren

• C. Seeli
• D. Patriki
• O.H. Ali
• A.-K. Blumenröther
• M.-C. Brüggen
• A. Nolting*
• C. Guillet*

Abteilungen

• Klinik für Dermatologie, Universitätsspital Zürich, Zürich, Schweiz

Adresse

Andrea Nolting
Klinik für Dermatologie
Universitätsspital Zürich
Rämistrasse 100
8091 Zürich, Schweiz
Email: [email protected]

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