Abstract

Adrenaline is the drug of choice for the treatment of anaphylaxis. Up to now, intramuscular administration using an autoinjector has been recommended in national and international guidelines as the first-line treatment for anaphylaxis. Various adrenaline autoinjectors are available on the German market as emergency medication for immediate treatment by medical laypersons and specialists. Recently, a nasally administered adrenaline preparation was introduced for the first time and is available on the market. There are mainly data on healthy control subjects, which show a good adrenaline level and an expected effect on blood pressure and heart rate. To date, there is little clinical experience in the world literature for patients with anaphylaxis in children/adolescents and none in adults or from Germany. Therefore, we would like to discuss theoretically the use of adrenaline via the nasal route of administration in the care of anaphylaxis patients and compare it with the intramuscular administration of adrenaline autoinjectors.

Author Details

Authors

• Regina Treudler¹
• Knut Brockow²
• Kirsten Beyer³,⁴
• Ludger Klimek⁵
• Lars Lange⁶
• Sabine Schnadt⁷
• Johannes Ring²
• Margitta Worm⁸

Departments

• ¹ Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin,
• ² Department of Dermatology and Allergology am Biederstein, Faculty of Medicine and Health, Technical University of Munich, Munich,
• ³ Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin,
• ⁴ German Center for Child and Adolescent Health (DZKJ), Berlin,
• ⁵ Center for Rhinology and Allergology, Wiesbaden,
• ⁶ Department of Pediatrics and Adolescent Medicine, St. Marien-Hospital, Bonn,
• ⁷ German Allergy and Asthma Association (DAAB). (DAAB), Mönchengladbach, and
• ⁸ Department of Dermatology, Venerology and Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany

Address

Prof. Dr. med. Regina Treudler, Institute of Allergology, Charité – Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
Email: [email protected]

Citation