Abstract

Atopic dermatitis (AD) is an inflammatory, multifactorial skin disease characterized by eczematous skin lesions, severe itching, and serious limitations in quality of life. Since 2016, TREATgermany has been a national clinical registry for patients with moderate to severe AD with around 2,550 participating patients, enabling the collection of physical, patient-reported social and psychological data as well as the collection of biosamples in routine care. TREATgermany is one of the largest academically managed AD registries in the world. This current review summarizes a selection of published analyses from registry data from TREATgermany, which retrospectively identified important correlations with regard to treatment response and safety, and investigated quality of life, performance, and mental health under everyday conditions. In addition, initial molecular signatures were identified from the blood and skin samples obtained from the patients included in the registry, which may be useful as prognostic markers.

Author Details

Authors

• Tatjana Honstein¹
• Barbara Kind²
• Dora Stölzl³
• Inken Harder³
• Sigrid Müller²
• Thomas Birkner²
• Luise Heinrich²
• Sascha Fischer¹
• Nicole Sander³
• Annice Heratizadeh¹
• Jochen Schmitt²
• Stephan Weidinger³
• Thomas Werfel¹

Departments

• ¹ Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover,
• ² Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, and
• ³ Department of Dermatology, Venereology and Allergology, Schleswig-Holstein University Hospital, Kiel Campus, Kiel, Germany

Address

Tatjana Honstein, Hannover Medical School, OE6600, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
Email: [email protected]

Citation