Abstract

Aims: We investigated sensitization to food allergens as a prognostic factor for wheezing in children with recurrent wheezing and compared serum club cell 16 (CC16) and surfactant protein D (SP-D) among these children with and without sensitization to food allergens. Materials and methods: Children with recurrent wheezing were enrolled in this prospective cohort study. Specific IgE to five common food allergens (Fx5) was assessed at baseline, and children were followed-up for 1 year for new-onset wheezing episodes. Baseline wheezing severity score, CC16, and SP-D levels were measured. Results: We enrolled 295 children (44 Fx5(+)). Poisson regression analysis revealed that Fx5 positivity changed the yearly frequency of wheeze by a factor of 1.66 (p = 0.05, 95% CI: (0.99 – 2.75)). Levels of CC16 and SP-D were not significantly different between the groups (p = 0.679 and p = 0.988). Conclusion: Sensitization to food allergens irrespective of food associated clinical allergy findings is associated with worse prognosis of wheezing in children.

Author Details

Authors

• Ozge Yılmaz¹
• Cecilia M. Patino²
• Fatma Taneli³
• Esra Toprak Kanik¹
• Ahmet Turkeli¹
• Ceyhun Gozukara³
• Sezen Irmak³
• Hasan Yuksel¹

Departments

• ¹ Manisa Celal Bayar University, School of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey,
• ² University of Southern California, Keck School of Medicine, Department of Preventive Medicine, Los Angeles, CA, USA, and
• ³ Manisa Celal Bayar University, School of Medicine, Department of Biochemistry, Manisa, Turkey

Address

Prof. Ozge Yilmaz, MD, Manisa Celal Bayar University School of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey
Email: [email protected]

Citation