Abstrakt

Background: In hereditary angioedema (HAE), numerous factors are known to trigger an attack. The possible influence of diet or recreational sports has been given little consideration in studies. The aim of our work was to investigate the influence of nutrition and physical activity in patients with HAE at the Leipzig ACARE Center.
Methods: Patients with HAE were given a self-designed questionnaire inquiring for family history, disease progression and encountered burden due to HAE, current therapy and disease control (angioedema control test; AECT) as well as the influence of diet and/or recreational sports on HAE attacks. Results: Inclusion of 30 patients (23 f, 77%) with a mean age of 49.5 ± 16.9 years and mean BMI of 25.1 ± 6.4 kg/m². 60% received prophylactic treatment and 37% received exclusively on-demand therapy. The mean AECT score was 10.9 ± 5.1, and patients reported 15.5 ± 26.9 days of absence due to HAE attacks in the last 12 months. 33% reported an association with food intake, in particular worsening of abdominal symptoms (n = 7), swelling of the extremities (n = 3), face, larynx, or genital area (n = 1 each). 70% reported regular exercise, most commonly cycling (n = 11), running or walking (n = 10), or strength training (n = 10). 62% reported a worsening of HAE due to recreational exercise.
Conclusion: Dietary factors and physical activity frequently led to an aggravation of HAE in our cohort and should be considered when counseling patients to avoid trigger factors.

Autoreninformation

Autoren

• J. Zarnowski¹
• R. Treudler^{1, 2}

Abteilungen

• ¹ Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R.,
• ² Institut für Allergieforschung, Charité – Universitätsklinikum Berlin, Campus Benjamin Franklin, Berlin

Adresse

Dr. med. Julia Zarnowski
Klinik für Dermatologie, Venerologie und Allergologie
Universitätsklinikum Leipzig A.ö.R.
Philipp-Rosenthal-Straße 69
04103 Leipzig
Email: [email protected]

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