Abstrakt

Modern management of hereditary angioedema (HAE) due to reduced C1 inhibitor (C1-INH) function or concentration (HAE-C1-INH) focuses on individualized therapeutic strategies to address the specific needs of children and adolescents as well as the severity of the disease. Psychosocial factors such as the burden of disease and therapy on quality of life and participation play an important role. New medications have already significantly improved the prognosis and health related quality of life in HAE patients, but not all of these therapies have yet been approved for children. Further treatment options that inhibit bradykinin effects are currently being investigated. They target factor XIIa, prekallikrein, plasma kallikrein, or the bradykinin B2 receptor. Modern research focuses on oral options or long-acting parenteral therapy approaches to further optimize care and, in particular, the needs of children. There are also initial developments in the field of gene therapy, which could represent a causal treatment option for HAE in the future.

Autoreninformation

Autoren

• M. Fasshauer¹
• B. Wedi²

Abteilungen

• ¹ Klinikum St. Georg Leipzig, Klinik für Kinder- und Jugendmedizin, ImmunDefektCentrum Leipzig (IDCL), Leipzig,
• ² Medizinische Hochschule Hannover (MHH), Klinik für Dermatologie, Allergologie und Venerologie, Interdisziplinäres Allergiezentrum der MHH, Behandlungszentrum für Hereditäre Angioödeme der MHH, Hannover

Adresse

Dr. med. Maria Fasshauer
Klinikum St. Georg Leipzig
Klinik für Kinder- und Jugendmedizin
Immundefektambulanz für Kinder und Erwachsene (gemäß §116 b, SGB V)
ImmunDefektCentrum Leipzig (IDCL)
Delitzscher Str. 141
04129 Leipzig
Email: [email protected]

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