Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy?
Ludger Klimek¹, Ulrike Förster-Ruhrmann², Heidi Olze², Achim G. Beule³,⁴, Adam M. Chaker⁵,⁶, Jan Hagemann⁷, Tilman Huppertz⁷, Thomas K. Hoffmann⁸, Stefan Dazert⁹, Thomas Deitmer¹⁰, Sebastian Strieth¹¹, Holger Wrede¹², Wolfgang W. Schlenter¹³, Hans-Jürgen Welkoborsky¹⁴, Barbara Wollenberg⁵, Sven Becker¹⁵, Fredericke Bärhold¹⁵, Felix Klimek¹, Ingrid Casper¹, Jaron Zuberbier², Claudia Rudack³, Mandy Cuevas¹⁶, Constantin A. Hintschich¹⁷, Orlando Guntinas-Lichius¹⁸, Timo Stöver¹⁹, Christoph Bergmann²⁰, Pascal Werminghaus²¹, Oliver Pfaar²², Jan Gosepath²³, Moritz Gröger²⁴, Caroline Beutner²⁵, Martin Laudien²⁶, Rainer K. Weber²⁷, Tanja Hildenbrand²⁸, Anna S. Hoffmann²⁹, Claus Bachert^30
1 Center for Rhinology and Allergology, Wiesbaden, ² HNO-University Clinic Charité, Berlin, ³ Clinic for Otorhinolaryngology, Münster University Hospital, ⁴ Clinic for Otorhinolaryngology, Head and Neck Surgery at Greifswald University Medical Center, ⁵ Department of Otolaryngology - Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, ⁶ Center of Allergy and Environment (ZAUM) of the Technical University of Munich, ⁷ Clinic and Polyclinic for Otolaryngology, University Medical Center Mainz, Mainz, ⁸ Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, Ulm, ⁹ Clinic for Otorhinolaryngology, Head and Neck Surgery, Ruhr University Bochum, St. Elisabeth Hospital, ^{1  0} German Society for Otorhinolaryngology, Head and Neck Surgery, Bonn, ^{1  1} Clinic and Polyclinic for Otorhinolaryngology, University Hospital Bonn, ^{1  2} Ear, nose and throat specialist, Herford, ^{1  3} Medical Association of German Allergists, Wiesbaden, ^{1  4} Clinic for Ear, Nose and Throat Medicine, Head and Neck Surgery, Nordstadt Clinic of the KRH, Hannover, ^{1  5} HNO-University Clinic Tübingen, ^{1  6} K Clinic and Polyclinic for Otolaryngology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, ^{1  7} Clinic and Polyclinic for Ear, Nose and Throat Medicine, University Hospital Regensburg, Regensburg, ^{1  8} Clinic for Otorhinolaryngology, Jena University Hospital, ^{1  9} Otorhinolaryngology University Clinic Frankfurt am Main, ^{2  0} HNO RKM ^{7  4  0}  Interdisciplinary Specialist Clinic, Düsseldorf, Germany, ^{2  1} Praxis für Hals-, Nasen-, Ohrenheilkunde und Allergologie, Düsseldorf, ^{2  2} Kl Clinic for Ear, Nose and Throat Medicine, University Hospital Giessen and Marburg GmbH, Marburg site, Philipps University Marburg, Marburg, ^{2  3} Clinic for Otorhinolaryngology, HSK Wiesbaden, ^{2  4} Clinic and Polyclinic for Otorhinolaryngology, University Hospital LMU Munich, ^{2  5} K Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, ^{2  6} Department of Otorhinolaryngology, Head and Neck Surgery, Kiel University, University Medical Centre Schleswig-Holstein, Kiel, ^{2  7} Clinic for Otorhinolaryngology, Karlsruhe Municipal Hospital, ^{2  8} Department of Ear, Nose and Throat Medicine, Freiburg University Medical Center, ^{2  9} Clinic for Ear, Nose and Throat Medicine, University Medical Center Hamburg-Eppendorf, ^{3  0} Kli Upper Airways Research Laboratory and Department of Oto-Rhino-Laryngology, Ghent University and Ghent, University Hospital, Ghent, Belgien