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Allergologie select, Volume 8 (2024) - 1st issue (12 - 17)

Role of FEF25–75 in characterizing outpatients with asthma in clinical practice
Giorgio Ciprandi¹, Irene Schiavetti²
¹ Allergy Clinic, Department of Outpatients, Casa di Cura Villa Montallegro, and ² Health Science Department, University of Genoa, Genoa, Italy

DOI 10.5414/ALX02453E

Abstract

Background: Asthma is characterized by variable airflow limitation. FEF_25–75 has been proposed as a reliable marker for bronchial obstruction, especially when FEV and FEV/FVC are normal. Objectives: To investigate the role of FEF_25–75 in patients with asthma seen in clinical settings. Materials and methods: The cross-sectional study included 439 (181 females and 255 males; mean age 39 years) outpatients with asthma who consecutively visited an allergy clinic for a routine assessment. History, physical examination, asthma control, and spirometry were evaluated. Results: FEF_25–75 was impaired (< 65% of predicted) in 136 (31%) outpatients. Considering only subjects with normal FEV and FEV/FVC, FEF_25–75 was impaired in 71 (19.6%) subjects. In this subset, impaired FEF_25–75 was associated with low FEV and FEV/FVC values (OR 0.91 and 0.85, respectively), and presence of asthma symptoms (OR 2.19). Conclusion: FEF_25–75 deserves adequate and careful consideration in patients with asthma and normal FEV and FEV/FVC, as the presence of impaired FEF_25–75 in this subset suggests a more specific approach.

Author Details

Authors

Departments

¹ Allergy Clinic, Department of Outpatients, Casa di Cura Villa Montallegro, and
² Health Science Department, University of Genoa, Genoa, Italy

Address

Giorgio Ciprandi, Allergy Clinic, Department of Outpatients, Casa di Cura Villa Montallegro, Genoa, Italy
Email: [email protected]

Citation

Giorgio Ciprandi and Irene Schiavetti.Role of FEF25–75 in characterizing outpatients with asthma in clinical practice. Allergologie Select. 2024; 8: 12-17. doi: 10.5414/ALX02453E.

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