Abstrakt

The associations of mold exposure, IgE-mediated sensitization, inflammatory markers and respiratory symptoms were analysed in 46 exposed and 23 non-exposed individuals. Both exposure and clinical symptoms were assessed by questionnaire. Specific (s)IgE to mold mixture (mx1) was significantly higher and found more frequently in exposed (41%) than non-exposed individuals (17%), which was not observed for sIgG to mold mix (Gmx6). Notably, exposed asthmatics were more frequently sensitized to molds (55%) compared to exposed non-asthmatics (18%). In addition, the serum concentrations of club cell protein, CC16 were significantly lower in exposed subjects, especially in asthmatics. Positive associations were observed among mold sensitization, asthma and mold exposure, but not in subjects with predominantly environmental sensitizations without mold sensitization. Thus, sIgE to mx1 but not sIgG to Gmx6 is a useful diagnostic marker to verify mold-associated respiratory symptoms.

Autoreninformation

Autoren

• S. Kespohl
• V. Liebers
• S. Maryska
• U. Meurer
• C. Litzenberger
• R. Merget
• M. Raulf

Abteilungen

• Institut für Prävention und Arbeitsmedizin der DGUV, Institut der Ruhr-Universität Bochum (IPA)

Adresse

Dr. rer. nat. Sabine Kespohl
Kompetenz-Zentrum Allergologie/Immunologie
Institut für Prävention und Arbeitsmedizin der DGUV
Institut der Ruhr-Universität Bochum (IPA)
Deutsche Gesetzliche Unfallversicherung e.V. (DGUV)
Bürkle-de-la-Camp-Platz 1
44789 Bochum
Email: [email protected]

Citation