Abstrakt

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Lung transplantation remains the only curative option for patients with end-stage disease. A missing understanding of pathomechanisms and phenotypes of COPD hampers the development of novel therapeutic approaches. COPD is a disease of the aging population and is characterized by impaired regenerative capacity of the lung. Regenerative capacity is reduced in the aging lung which is caused by different cellular processes. Among those, cellular senescence is a main mechanism which is increased in COPD lungs. Cellular senescence impairs stem cell capacity and contributes to aging-associated chronic inflammation, so-called inflammaging. The therapeutic targeting of cellular senescence showed first promising results in preclinical experiments and suggests cellular senescence as a main target for personalized medicine approaches aiming at restoring the regenerative capacity of the COPD lung.

Autoreninformation

Autoren

• N. Bramey¹
• B. Schmeck^{2, 3, 4}
• M. Lehmann^{1, 2}

Abteilungen

• ¹ Institut für Lungengesundheit und Immunität, Helmholtz Zentrum München, Mitglied des Deutschen Zentrums für Lungenforschung (DZL),
• ² Institut für Lungenforschung, Philipps-Universität Marburg, Mitglied des Deutschen Zentrums für Lungenforschung (DZL),
• ³ Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universität Marburg,
• ⁴ Mitglied des Deutschen Zentrums für Lungenforschung (DZL) und des Deutschen Zentrums für Infektionsforschung (DZIF)

Adresse

Prof. Dr. Mareike Lehmann
Institut für Lungenforschung
Philipps University Marburg
Hans-Meerwein-Strasse 2
35043 Marburg
Email: [email protected]

Citation