Descriptive analysis of adverse drug reaction reports for hypersensitivity reactions stratified in relation to different beta-lactam antibiotics
Diana Dubrall1,2, Maike Schulz3, Matthias Schmid1, Bernhardt Sachs2,4
1 Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Venusberg-Campus 1 , Bonn, Germany, 2 Research Department, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany, 3 Central Institute for the Provision of Health Care by Statutory Health Insurance Physicians in the Federal Republic of Germany, Berlin, Germany, 4 Clinic for Dermatology and Allergology, University Hospital RWTH Aachen, Aachen, Germany
DOI 10.5414/ALX02189E
Abstract
β-lactam antibiotics (BLA) are commonly reported to induce hypersensitivity reactions. However, β-lactam antibiotic-stratified analyses are rare. In the presented study, β-lactam antibiotic associated hypersensitivity reactions were analyzed in the European adverse drug reaction (ADR) database. 923, 38, 222, and 99 hypersensitivity reports for penicillins and first-, second- and third-generation cephalosporins were reported. Differences with regard to demographical parameters, seriousness and types of hypersensitivity reactions, as well as in the number of hypersensitivity reports per outpatient prescriptions were observed between the different β-lactam antibiotics. The number of ADR reports classified as serious was higher for all generations of cephalosporins compared to penicillins. Additionally, anaphylactic reactions were more often reported for first- and second-generation cephalosporins compared to third-generation cephalosporins and penicillins, while bullous reactions were more often reported for first- and third-generation cephalosporins as opposed to second-generation cephalosporins and penicillins. The observed differences may be caused by differences between β-lactam antibiotics and their routes of administration (oral, intravenous), the patient populations, or the reporting of ADRs. Due to the methodological limitations of ADR database analysis, no conclusions can be drawn whether and to what extent the aforementioned factors influenced our results.
Author Details
Authors
Departments
- 1 Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Venusberg-Campus
- 1 , Bonn, Germany,
- 2 Research Department, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany,
- 3 Central Institute for the Provision of Health Care by Statutory Health Insurance Physicians in the Federal Republic of Germany, Berlin, Germany,
- 4 Clinic for Dermatology and Allergology, University Hospital RWTH Aachen, Aachen, Germany
Address
Dr. Diana Dubrall, Institute for Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Venusberg Campus 1, Building 11, 53127 Bonn, Germany
Email:
[email protected]
Citation
Diana Dubrall, Maike Schulz, Matthias Schmid, and Bernhardt Sachs.Descriptive analysis of adverse drug reaction reports for hypersensitivity reactions stratified in relation to different beta-lactam antibiotics. 2022; 6: 42-60. doi: 10.5414/ALX02189E.
