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Allergologie select, Volume 5 (2021) - 1st Issue (187 - 194)

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report
Miguel Mayo-Yáñez1,2, Andrea Díaz-Díaz3, Juan C. Vázquez-Barro1,4, Jesús Herranz González-Botas1,5, Angélica Figueroa3, Carlos S. Martín-Martín5,6
1 Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of A Coruña (CHUAC), A Coruña, Galicia, 2 Clinical Research in Medicine, International Center for Doctorate and Advanced Studies (CIEDUS), University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, 3 Epithelial Plasticity and Metastasis Group, Biomedical Research Institute of A Coruña (INIBIC), University Hospital Complex of A Coruña (CHUAC), University of A Coruña (UDC), A Coruña, Galicia, 4 School of Educational Sciences, University of A Coruña (UDC), A Coruña, Galicia, 5 School of Medicine and Odontology, University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain, and 6 Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of Santiago de Compostela (CHUS), Santiago de Compostela, Galicia, Spain

   

 

DOI 10.5414/ALS400537

Abstract

Aim: To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis. Methods: In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow. Results: Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 – 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010). Conclusions: It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a causeeffect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.

Author Details

Authors

Departments

  • 1 Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of A Coruña (CHUAC), A Coruña, Galicia,
  • 2 Clinical Research in Medicine, International Center for Doctorate and Advanced Studies (CIEDUS), University of Santiago de Compostela (USC), Santiago de Compostela, Galicia,
  • 3 Epithelial Plasticity and Metastasis Group, Biomedical Research Institute of A Coruña (INIBIC), University Hospital Complex of A Coruña (CHUAC), University of A Coruña (UDC), A Coruña, Galicia,
  • 4 School of Educational Sciences, University of A Coruña (UDC), A Coruña, Galicia,
  • 5 School of Medicine and Odontology, University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain, and
  • 6 Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of Santiago de Compostela (CHUS), Santiago de Compostela, Galicia, Spain

Address

Miguel Mayo-Yáñez, MD, MSc, Otorhinolaryngology, Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coruña (CHUAC), As Xubias 84, 15006, A Coruña, Spain
Email: [email protected]

Citation

Miguel Mayo-Yáñez, Andrea Díaz-Díaz, Juan C. Vázquez-Barro, Jesús Herranz González-Botas, Angélica Figueroa, and Carlos S. Martín-Martín.Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report. 2021; 5: 187-194. doi: 10.5414/ALS400537.

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