Anti-inflammatory effect of herbal traditional medicine extract on molecular regulation in allergic asthma
Xiaopeng Sun1, Entezar Mehrabi Nasab2, Seyyede Masoume Athari3, Seyyed Shamsadin Athari4
1 Department of Otolaryngology, Second Affiliated Hospital of Xi’an Medical College, Xi’an, China, 2 Cardiologist, Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, 3 Department of Biology, Faculty of Basic Sciences, Maragheh University, Maragheh, and 4 Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
DOI 10.5414/ALS400545
Abstract
Asthma is an important global health problem, and the main cause of asthma is allergic reaction and immune system dysregulation. Airway inflammation causes bronchial narrowing, and goblet cell hyperplasia leads to mucus hypersecretion that leads to airflow obstruction and difficulty breathing. The Th2 cytokines can induce allergic asthma. Camellia, Adhatoda, and Glycyrrhiza are the traditional medicines that are used in some countries. In the current study, we evaluated three herbal extracts on airway inflammatory responses in asthmatic mice. The asthma model was induced in mice that were divided into 6 groups: Phosphate-buffered saline (PBS) group, ovalbumin (OVA) group, OVA-budesonide group, OVA-Glycyrrhiza group, OVA-Camellia group, and OVA-Adhatoda group. Measurements of IL-4, IL-5, IL-13, glutamate oxaloacetate transaminase (GOT), glutamic pyruvic transaminase (GPT), IgE, histamine, percentages of eosinophils in bronchoalveolar lavage fluid (BALf), gene expression of COX-2, CCL24, CCL11, eotaxin, and histopathological study of lung were done. Adhatoda significantly attenuated the IL-4, IgE, and histamine levels. Glycyrrhiza attenuated the levels of IL-5, IL-13, GTP, GOT (on day 51), mRNA expression of eotaxin, CCL24, CCL11, and COX-2, eosinophil infiltration, mucus secretion, and goblet cell hyperplasia. Camellia decreased IL-13, GTP, COX-2 mRNA expression, mucus secretion, and goblet cell hyperplasia on day 31 and 51. We evaluated effect of three plants on allergic bio-factors. Glycyrrhiza as main anti-inflammatory treatment, Adhatoda as anti-allergic, and Camellia as anti-mucus releasing treatment can be used in attacks of allergic asthma.
Author Details
Authors
Departments
- 1 Department of Otolaryngology, Second Affiliated Hospital of Xi’an Medical College, Xi’an, China,
- 2 Cardiologist, Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran,
- 3 Department of Biology, Faculty of Basic Sciences, Maragheh University, Maragheh, and
- 4 Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Address
Dr. Seyyed Shamsadin Athari, Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Mahdavi street, 4513956111 Zanjan, Iran
Email:
[email protected]
Citation
Xiaopeng Sun, Entezar Mehrabi Nasab, Seyyede Masoume Athari, and Seyyed Shamsadin Athari.Anti-inflammatory effect of herbal traditional medicine extract on molecular regulation in allergic asthma. 2021; 5: 148-156. doi: 10.5414/ALS400545.
