Abstract

A retrospective data analysis was performed to investigate the association between polypharmacy and adverse events using three different spontaneous adverse event reporting system databases. Multivariate logistic regression analyses were performed to investigate the association between the number of drugs and adverse events, including hepatic disorders, renal disorders, hypersensitivity, and extrapyramidal syndrome. The results showed that the risk of hepatic and renal disorders increased with the number of drugs. Thus, decreasing the number of drugs may reduce the risk of hepatic and renal disorders. Furthermore, attention should be given to specific drugs that may cause hypersensitivity and extrapyramidal syndrome.

Author Details

Authors

• Takayuki Mabuchi^{1, 3}
• Kouichi Hosomi^{1, 2}
• Satoshi Yokoyama^{1, 2}
• Mitsutaka Takada^{1, 2}

Departments

• ¹ Division of Clinical Drug Informatics, Kindai University Graduate School of Pharmacy,
• ² Division of Clinical Drug Informatics, School of Pharmacy, Kindai University, and
• ³ Maruzen Pharmacy, Osaka, Japan

Address

Mitsutaka Takada, PhD
Division of Clinical 
Drug Informatics
School of Pharmacy, Kindai University
3-4-1, Kowakae, Higashi-osaka
Osaka, 577-8502, Japan
Email: takada@
phar.kindai.ac.jp

Citation