Abstrakt

Breast cancer is a multifactorial disease. It may have a lot of individual causes, e.g., genetic, endocrinologic, psychical, infectious, immunological, and toxicological subcauses. If possible, a cause-oriented diagnosis, therapy, and prevention should be applied. This article addresses the prevention of breast cancer with particular reference to endocrinological and environmental health aspects. Endocrinological aspects: A frequent constellation possibly increasing the individual breast cancer risk(s) may be ovarian dysfunction (estrogen dominance, progesterone deficiency, and progesterone resistance), cholecalciferol deficiancy, thyroid dysfunction (hypothyreosis, Hashimoto’s thyroiditis), adrenocortical dysfunction (especially DHEA deficiency), pancreatic dysfunction (particlularly insulin resistance), and metabolic syndrome. For breast cancer prevention and also for follow-up (especially in cases of hormone-dependent breast cancer) it may be important to take into account these endocrinological aspects, to measure and optimize these hormones, and thus to r possibly educe the individual risk of breast cancer (recurrence). In addition, a possible deficiency of selenium or zinc as well as reduced glutathione (GSH) should be detected and treated individually. Environmental medical aspects: Also various ubiquitous endocrine disruptors (E.D.) may promote pathological endocrine situations, e.g., estrogen dominance, progesterone deficiency, hypothyreosis, Hashimoto’s thyroiditis, DHEA deficiency, insulin resistance, and metabolic syndrome. A variety of synergisms between E.D. (especially heavy metals) and hormones is well known, also there may be various possible interactions between a lot of E.D. and tamoxifen and aromatase inhibitors. If patient history includes (possible) exposure to heavy metals, a heavy metal mobilization test, e.g. with DMPS, might be indicated. If the heavy metal values in the urine are increased, there may be an indication for a targeted, customized, laboratory-controlled heavy metal detoxification (e.g., with DMPS, DMSA, DPTA, EDTA). This may be useful within the context of a causal treatment/prevention/ relapse prophylaxis.

Autoreninformation

Autoren

• C. Schulte-Uebbing¹
• P. Jennrich²
• I. Gerhard³
• V. Zahn⁴
• I.D. Craiut⁵

Abteilungen

• ¹ Frauenarzt, Onkologie, Endokrinologie, Immunologie, Umweltmedizin, München,
• ² Allgemeinarzt, klinische Metalltoxikologie, Umweltmedizin, Würzburg,
• ³ ehem. Ambulanz für Umweltmedizin, Universitäts-Frauenklinik Heidelberg, Netzwerk Frauengesundheit, Heidelberg,
• ⁴ emeritierter Ärztlicher Direktor der Frauenklinik, Klinikum Straubing, Akademisches Lehrkrankenhaus der TU München,
• ⁵ Ordinarius für Geburtshilfe und Gynäkologie, International University Oradea, Ärztlicher Direktor, Euclid Clinic, Oradea, Rumänien

Adresse

Prof. Dr. med C. Schulte-Uebbing
Umweltmedizinisches Therapiezentrum am Dom
Weinstraße 7a
D–80333 München
Email: [email protected]

Citation