Successful treatment of gallbladder neuroendocrine carcinoma with combined chemo-radiotherapy: A case report and literature review
P.-C. Lin1,2, Y.-C. Lai1,2, J.-I. Lai1,2, S.-Y. Hsu3, W.-S. Wang2,4
1 National Yang-Ming University School of Medicine, 2 Department of Medicine,
National Yang-Ming University Hospital, 3 Kaohsiung Medical University and
4 Department of Medicine, National Yang-Ming University Hospital, Yilan, Taiwan,
Republic of China
DOI 10.5414/CPP49403
Abstract
Neuroendocrine tu mors (NETs) oc cur in the bronchopulmonary sys tem. Extrapulmonary NETs are rare and are con - sid ered to ac count for 2.5 – 5% of all NETs, with more than 60% of these tu mors oc cur - ring along the gas tro in tes ti nal tract, in clud ing primary NET of the gall blad der. Pri mary NETs of the gall blad der have been clas si fied as carcinoid, neuro endo crine car ci noma or het er o ge neous car ci noma. Cur rently, the main treat ment of neuro endo crine car ci noma re mains sur gery. The role of ra dio ther apy and che mo ther apy is un de fined be cause of the pau city of data. In ad vanced cases, che mo - ther apy has been pre scribed with such ef fec - tive agents as cisplatin, carbo platin, etoposide and paclitaxel. Here we re port a case of a 64-year-old Tai wan ese male pa tient with neuroendocrine car ci noma of the gall bladder who received com bined chemo- radiotherapy (CCRT) with cisplatin, 5- fluor ouracil and leuco vorin (PFL) from June 2009 un til now, and whose dis ease is sta ble. CCRT with PFL may be a pos si ble reg i men for high-grade neuroendocrine carcinoma of the gall bladder.
Author Details
Authors
Departments
- 1 National Yang-Ming University School of Medicine,
- 2 Department of Medicine,
National Yang-Ming University Hospital, - 3 Kaohsiung Medical University and
- 4 Department of Medicine, National Yang-Ming University Hospital, Yilan, Taiwan,
Republic of China
Address
P.-C. Lin, MD
Department of Medicine
National Yang-Ming University Hospital
No. 152, Xin-Min Road,
I-lan, 26042 Taiwan
Email:
nicklin1103tw@ya hoo.com.tw
Citation
P.-C. Lin, Y.-C. Lai, J.-I. Lai, S.-Y. Hsu and W.-S. Wang.Successful treatment of gallbladder neuroendocrine carcinoma with combined chemo-radiotherapy: A case report and literature review. 2011; 49: 403-408. doi: 10.5414/CPP49403.