Evaluation of methylprednisolone aceponate, tacrolimus and combination thereof in the psoriasis plaque test using sum score, 20-MHz-ultrasonography and optical coherence tomography
K. Buder, P. Knuschke, G. Wozel
Department of Dermatology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
DOI 10.5414/CPP48814
Abstract
Background: Despite new treatment options with systemic disease modifiers, topical therapy – especially as combination therapy – plays an important role in psoriasis treatment. Methods: Antipsoriatic efficacy of methylprednisolone aceponate ointment (MPA), tacrolimus 0.1% ointment (FK506) and their combination (MPA+FK506) were investigated in a double-blind randomized pilot study using the psoriasis plaque test. Agents and corresponding placebos were applied once daily under occlusion for 11 days. Test sites were evaluated by sum score (erythema, scaling, infiltration), objective assessment by 20-MHz-sonography and optical coherence tomography (OCT). Results: After 11 days, the sum score significantly improved from baseline value in FK506-treated skin (9.6 vs. 2.9, p < 0.0001). MPA led to a significant improvement of the sum score (9.4 vs. 0.6, p < 0.0001). Combination therapy showed results similar to MPA monotherapy (9.4 vs. 0.4, p < 0.0001). These findings were confirmed by 20-MHz-sonography and OCT data. Conclusion: FK506 is moderately effective in chronic plaque-type psoriasis in our model. Combination therapy with FK506+MPA has no additive effect compared to MPA alone.
Author Details
Authors
Departments
- Department of Dermatology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Address
Prof. Dr. med. G. Wozel
Department of Dermatology
University Hospital Carl Gustav Carus
Dresden University of Technology
Fetscherstraße 74
01307 Dresden, Germany
Email:
[email protected]
Citation
K. Buder, P. Knuschke and G. Wozel.Evaluation of methylprednisolone aceponate, tacrolimus and combination thereof in the psoriasis plaque test using sum score, 20-MHz-ultrasonography and optical coherence tomography. 2010; 48: 814-820. doi: 10.5414/CPP48814.
