Abstract

The main unfavorable effects observed in gestosis include the increased blood pressure with the defective uteroplacental flow. The aim of the study was to assess the effect of isradipine upon fetal vessels resistance experimentally induced, oxygen consumption and oxygen transfer. We completed and devoted our previous perfusion experiments of human placental lobule to the scope of problems concerning placental metabolic activity [Skoczynski et al. 2005]. The research used the experimental model described by Schneider et al. [1972]. Twelve perfusions of the human placental cotyledons were performed. They lasted 120 min each. We obtained constant increase in perfusion pressure from the 60th min of the study. The experiment during which constant, increased perfusion pressure is obtained after administration of stable thromboxane A₂ analogue U46619 seems to imitate vascular motor activity in vivo in preeclampsia. From this moment of study, isradipine was administered along with U46619 into the fetal circulation. Perfusion pressure, oxygen transfer and oxygen consumption were calculated. Isradipine effects upon the feto-placental vessels were evident in the experiment. The drug lowered the experimentally increased perfusion pressure. It also improved the oxygen transfer. The changes of oxygen consumption were occasional. The present studies indicate that oxygen transfer seems to depend on uteroplacental flow. Moreover, physical factors, circulating vasoactive substances may mediate oxygen consumption.

Author Details

Authors

• M. Skoczynski
• A. Kwasniewska

Departments

• Department of Obstetrics and Gynecology, University of Medicine, Lublin, Poland

Address

Dr. M. Skoczynski
Klinika Poloznictwa
ul. Staszica 16
20-081 Lublin, Poland
Email: [email protected]

Citation