Abstract

The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.

Author Details

Authors

• H.Y. Lane¹,³
• H.C. Liu⁴
• C.M. VanDenBerg²
• M.H. Su³,⁵
• M.W. Jann²
• W.H. Chang¹

Departments

• ¹ Department of Psychiatry, Tzu-Chi General Hospital and Tzu-Chi University, Hualien, Taiwan
• ² Mercer University, Southern School of Pharmacy, Atlanta, GA, USA,
• ³ The Graduate Institute of Life Sciences, National Defense Medical Center,
• ⁴ Hung-Tzu Psychiatric Hospital, and
• ⁵ The School of Pharmacy, National Defense Medical Center, Taipei, Taiwan

Address

Dr. W.H. Chang; Department of Psychiatry, Tzu-Chi General Hospital, 707, Section 3, Chung-Yan Road, Hualien City, Taiwan 970

Citation