Abstract

Objective: To compare the efficacy, safety, cost and effects on platelet aggregation of unfractionated heparin and low-molecular weight heparin in unstable angina patients. Patients and methods: Ninety-three patients with unstable angina were randomized to receive either unfractionated heparin (UFH) or enoxaparin in an open design clinical trial with blinded end point evaluation. The effects of the heparins on platelet aggregation were also compared. Results: The composite end point of myocardial infarction, cardiac death, recurrent angina and need for intervention was observed in 62% of patients treated with UFH and in 37% of patients treated with enoxaparin (RR 1.7, 95% CI 0.75 to 3.71, p = 0.04). There was no difference in the frequency or severity of adverse events. A cost-effectiveness analysis showed both the heparins to be similar. Platelet aggregation was inhibited to a greater extent by UFH when compared to enoxaparin. Conclusions: Enoxaparin appears to be superior in efficacy to UFH and similar to UFH in safety. No difference in costs was detected in this study. The greater inhibition of platelet aggregation observed in the case of UFH compared to enoxaparin indicates that there may be more bleeding complications with UFH.

Author Details

Authors

• S. Malhotra¹
• V.K. Bhargava¹
• A. Grover²
• P. Pandhi¹
• Y.P. Sharma²

Departments

• ¹ Department of Pharmacology, and
• ² Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Address

Prof. Dr. V.K. Bhargava; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Email: [email protected]

Citation