Abstract

Autophagic vacuoles are the morphological hallmark in a wide variety of human skeletal muscle disorders. The present review summarizes recent novel insights in the physiology and pathophysiology of autophagic vacuole formation in skeletal muscle. Special emphasis will be given to the relationship between vacuolar changes and lysosomal and non-lysosomal protein degradation pathways, the diagnostic significance of rimmed and round vacuoles and novel therapeutic options related to autophagic pathways.

Author Details

Authors

• B. Schoser

Departments

• Department of Neurology, Friedrich Baur Institute, Ludwig Maximilians University Munich, Germany

Address

B. Schoser, MD; Friedrich Baur Institute, Department of Neurology, Ludwig Maximilians University Munich, Ziemssenstraße 1a, 80336 Munich, Germany
Email: [email protected]

Citation