Clinical Neuropathology, Volume 45 (2026) - March/April (42 - 48)

Retrospective neuropathologic analysis of adult spinal tumors in a single neuroscience center 2018 – 2023
Ciara O’Donoghue2, Beibhinn Wilkins2, Alan Beausang1, Jane Cryan1, Michael Farrell1, Jennifer Garry1, Ciara Heeney1, Josephine Heffernan1, Rachel Howley1, Niamh Kernan1, Seamus Looby1, Arooj Fatima1, Alan Power2, Ashling Spillane1, Andrea Walsh1, Francesca M. Brett1, 2
1 Department of Clinical Neurological Sciences, Beaumont Hospital, and 2 Trinity College, Dublin, Ireland

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DOI 10.5414/NP301722

Abstract

Spinal tumors are classified as extradural or intradural. The latter are further divided into intradural/extramedullary and intradural/intramedullary. The location, coupled with radiological assessment, intraoperative findings, size of biopsy, histological features, and molecular analysis serve to aid accurate diagnosis. We compiled a neuropathologic database of all adult (over 18 years) brain and spinal cord tumors diagnosed at the National Neuroscience Centre in Beaumont Hospital from 2018 to 2023. In this retrospective audit we identified 3,987 tumors, of which 90% (3,596) were intracranial and 10% (391) were spinal. The majority of the spinal tumors were intradural (n = 198) with extradural (n = 122) and intramedullary (n = 71) being much less common. In this review we outline the commonest tumors encountered, by location and age group, unusual tumors that may come to light, and difficulties that may arise, specifically with sampling.

Author Details

Authors

Departments

  • 1 Department of Clinical Neurological Sciences, Beaumont Hospital, and
  • 2 Trinity College, Dublin, Ireland

Address

Francesca Brett
Department of Clinical Neurological Sciences
Beaumont Hospital
PO Box 1279
Dublin 9, Ireland
Email: [email protected]

Citation

Ciara O'Donoghue, Beibhinn Wilkins, Alan Beausang, Jane Cryan, Michael Farrell, Jennifer Garry, Ciara Heeney, Josephine Heffernan, Rachel Howley, Niamh Kernan, Seamus Looby, Arooj Fatima, Alan Power, Ashling Spillane, Andrea Walsh, Francesca M B.Retrospective neuropathologic analysis of adult spinal tumors in a single neuroscience center 2018 – 2023. Clin Neuropathol. 2026; 46: 42-48. doi: 10.5414/NP301722. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41914602/; PMID: 41914602.

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