Abstract

Objective: To evaluate the effects of anesthesia with dexmedetomidine (DEX) and closed-loop target-controlled inhalation of sevoflurane on the intestinal flora and levels of serum pain mediators in patients undergoing abdominal surgery. Materials and methods: A cohort of 100 patients who had received abdominal surgery in the period February 2022 to March 2024 were recruited in this retrospective study. The observational group (n = 50) received anesthesia with DEX plus closed-loop target-controlled inhalation of sevoflurane, and the control group (n = 50) received anesthesia with DEX alone. Inter-group comparisons were made for sex, age, etiology, and educational level and for the quality of anesthesia (anesthesia recovery time and induction time), changes in the intestinal flora (Shannon index and Simpson index) and levels of serum pain mediators (prostaglandin E₂ (PGE₂), tumor necrosis factor-α (TNF-α), and 5-hydroxytryptamine (5-HT)) before anesthesia and 5 minutes after anesthesia induction. Results: The anesthesia recovery and induction time were significantly shorter in the observational group than in the control group (p < 0.05). At 5 minutes after anesthesia induction, both the Shannon index and Simpson index were significantly lower in the control group than in the observation group (p < 0.05), and the levels of PGE₂, TNF-α, and 5-HT were also significantly lower in the observation group (p < 0.05). Conclusion: Evidence was provided showing that anesthesia with DEX plus closed-loop target-controlled inhalation with sevoflurane improves the quality of the anesthesia, reduces the levels of serum pain mediators, and has potentially beneficial effects on the intestinal flora in patients undergoing abdominal surgery.


Author Details

Authors

• Qiaoying Pan¹
• Libin Mao²,³
• Qinglin Lv⁴

Departments

• ¹ Department of Anesthesiology, Ninghai County Traditional Chinese Medicine Hospital, Ningbo, Zhejiang Province,
• ² Department of Anesthesiology, Huangshi Maternity and Children’s Health Hospital, Affiliated Maternity and Children’s Health Hospital of Hubei Polytechnic University,
• ³ Huangshi Key Laboratory of Birth Defects Prevention, Huangshi, Hubei Province, and
• ⁴ Department of Pharmacy, Chongqing Armed Police General Hospital, Chongqing, China

Address

Qinglin Lv, MBBS, Department of Pharmacy, Chongqing Armed Police General Hospital, Chongqing 400000, China
Email: [email protected]

Citation