Impact of extracorporeal membrane oxygenation on antituberculosis drug concentrations: A case study and pharmaceutical care strategies Yidan Xu, Fei Lv, Xing Yu Pharmacy Department, Public Health Clinical Center of Chengdu, Chengdu, China
DOI 10.5414/CP204865
Abstract
Background: Extracorporeal membrane oxygenation (ECMO) provides life support for critically ill tuberculosis (TB) patients. However, during ECMO therapy, significant fluctuations in the plasma concentration of anti-TB drugs occur due to drug adsorption in the ECMO circuit, hemodilution, and metabolic disturbances. Materials and methods: This single-case study monitored the plasma concentration of anti-TB drugs in a TB patient supported by ECMO. Results: The differences in peak plasma concentrations (Cmax) measured at the end of ECMO support vs. 7 days after ECMO withdrawal were as follows: isoniazid (66%), linezolid (63%), ethambutol (56%), and levofloxacin (12%). Conclusion: We analyzed ECMO’s impact on drug concentrations and implemented therapeutic drug monitoring to optimize therapy. However, this single-case study has inherent limitations; future multi-center studies are warranted to validate these findings.
Yidan Xu, Fei Lv, Xing Yu.Impact of extracorporeal membrane oxygenation on antituberculosis drug concentrations: A case study and pharmaceutical care strategies .Int J Clin Pharmacol Ther.2026; 64: 219-225. doi: 10.5414/CP204865. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41508881/; PMID: 41508881.
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