Int. Journal of Clinical Pharmacology and Therapeutics, Volume 64 (2026) - March (154 - 158)

Semaglutide-induced transient intestinal ischemia: A case report

Pavan Kumar Reddy Kalluru1, Apoorva Cherukuri1, Deekshitha Kuchi2, Antonia Topacio1
1 West Anaheim Medical Center, Anaheim, CA, USA, and 2 NTR University of Health Sciences, Ramavarappadu, Vijaywada, Andhra Pradesh, India

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DOI 10.5414/CP204861

Abstract

Obesity is a global health issue that impacts millions of people worldwide. Semaglutide is a glucagon-like peptide-1 receptor agonist that was initially developed as a treatment for type 2 diabetes mellitus under the brand name Ozempic. Additional studies showed semaglutide at larger doses (marketed as Wegovy) to be an effective medication for weight management. Wegovy for managing obesity is typically well tolerated; however, there have been reports of gastrointestinal adverse effects. Only 1 case of Wegovy-induced transient intestinal ischemia has been documented, making it extremely unusual. Here, we report the case of a 50-year-old man who experienced transient intestinal ischemia following his first Wegovy dosage.

Author Details

Authors

Departments

  • 1 West Anaheim Medical Center, Anaheim, CA, USA, and
  • 2 NTR University of Health Sciences, Ramavarappadu, Vijaywada, Andhra Pradesh, India

Address

Pavan Kumar Reddy Kalluru, MD
West Anaheim Medical Center
3033 West Orange Avenue
Anaheim, CA 92804, USA
Email: [email protected]

Citation

Pavan Kumar Reddy Kalluru, Apoorva Cherukuri, Deekshitha Kuchi, Antonia Topacio.Semaglutide-induced transient intestinal ischemia: A case report
. Int J Clin Pharmacol Ther. 2026; 64: 154-158. doi: 10.5414/CP204861. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41467632/; PMID: 41467632.

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