A four-hour urine sample is accurate in measuring creatinine clearance in acute kidney injury John Mellas, Alexander Mellas Nephrology and Hypertension Specialists, Division of Clinical Nephrology Research, St, Louis, MO, USA
DOI 10.5414/CN111842
Abstract
A rapid, real-time, and accurate bedside method to measure creatinine clearance in acute kidney injury is not available to the clinician. Previously described methods relied on serum creatinine with a time interval of 24 hours between serum collections suggesting that the data was either retrospective and reflected the creatinine clearance prior to the second serum collection, and that a prospective measure would require an additional 24-time delay to estimate the creatinine clearance going forward. This paper describes a mathematical proof of concept that a 4-hour urine collection is accurate in measuring creatinine clearance in acute kidney injury, providing the clinician a valuable tool in treating the patient with acute kidney injury.
Nephrology and Hypertension Specialists, Division of Clinical Nephrology Research, St, Louis, MO, USA
Address
John Mellas, MD
6 Glaizeview Road
Chesterfield 63017, MO, USA Email: [email protected]
Citation
John Mellas, Alexander Mellas.A four-hour urine sample is accurate in measuring creatinine clearance in acute kidney injury .Clin Nephrol.2026; 105: 97-102. doi: 10.5414/CN111842. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41235416/; PMID: 41235416.
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