Abstract

Cytomegalovirus is a common opportunistic infection that often affects individuals with impaired immune function. It may present with a variety of clinical manifestations. Treatment for ulcerative colitis (UC) usually requires immunosuppressants and steroids, increasing patients’ susceptibility to cytomegalovirus infection. We report the case of a 53-year-old female patient with corticosteroid-resistant UC and recurrent cytomegalovirus infection. The patient had exacerbations, and the diagnosis of cytomegalovirus infection was confirmed through serology and detection of high levels of cytomegalovirus DNA in biopsies using quantitative polymerase chain reaction (PCR). After requiring intravenous ganciclovir, the patient improved. However, she had further relapses requiring treatment with foscarnet, with marked improvement in symptoms and endoscopic results. This case shows the importance of evaluating acute cytomegalovirus infections in patients with corticosteroid resistance. Quantitative PCR appears to be a valuable tool in guiding treatment decisions. In addition, the case is evidence for the satisfactory efficacy of foscarnet in managing cytomegalovirus infections.


Author Details

Authors

• Shema Ayadi
• Nadine Ghithia
• Nouha Trad
• Asma Mensi
• Emna Belhadj Mabrouk
• Leila Mouelhi
• Radhouene Dabbeche

Departments

• Gastroenterology Department, Charles Nicolle Hospital, Faculty of Medicine of Tunis, University Tunis El Manar Tunis, Tunisia

Address

Trad Nouha
Gastroenterology Department
Charles Nicolle Hospital
Faculty of Medicine of Tunis
University Tunis El Manar Tunis, Tunisia
Email: [email protected]

Citation