Int. Journal of Clinical Pharmacology and Therapeutics, Volume 64 (2026) - January (38 - 46)

Amyotrophic lateral sclerosis rehabilitation management and non-pharmacological symptomatic treatment: A review

Yuetong Shan1*, Wei Jing1*, Haihan Zhang1, Yizhou Liu1, Shangyu Wei1, Feifei Wu2, Weidong Pan1, 3
1 Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinses Medicine, 2 Department of Neurology, Shanghai Pudong New Area Gongli Hospital, and 3 Encephalopathy Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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DOI 10.5414/CP204744

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that lacks effective treatment options for the prevention of progression. Relieving swallowing difficulties, reducing breathing difficulties, and alleviating muscle spasms are essential to improving the quality of life in patients with ALS. Many symptoms can be treated clinically with medication; however, the evidence level of related research is relatively low. Rehabilitation management can aid in improving various functional impairments and enhancing quality of life. This review introduces and describes the relevant evaluations of rehabilitation and nonpharmacological symptomatic treatment methods for functional disorders from the perspectives of motor and nonmotor symptoms. This review may promote the popularization of ALS rehabilitation management and provide an additional reference for ALS treatment.

*Yuetong Shan and Wei Jing contributed equally to this work.

Author Details

Authors

Departments

  • 1 Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinses Medicine,
  • 2 Department of Neurology, Shanghai Pudong New Area Gongli Hospital, and
  • 3 Encephalopathy Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

Address

Dr. Feifei Wu
Department of Neurology
Shanghai Pudong New Area Gongli Hospital
Shanghai 200135, China
or
Professor Weidong Pan
Department of Neurology
Shuguang Hospital Affiliated to Shanghai
University of Traditional Chinese Medicine
Shanghai 201203, China
Email: [email protected]; [email protected]

Citation

Yuetong Shan, Wei Jing, Haihan Zhang, Yizhou Liu, Shangyu Wei, Feifei Wu, Weidong Pan.Amyotrophic lateral sclerosis rehabilitation management and non-pharmacological symptomatic treatment: A review
. Int J Clin Pharmacol Ther. 2026; 64: 38-46. doi: 10.5414/CP204744. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41065069/; PMID: 41065069.

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