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Int. Journal of Clinical Pharmacology and Therapeutics, Volume 63 (2025) - April (160 - 163)

Cardiovascular safety profile of JAK inhibitors and ethnic factors in Asians: A signal detection study using the Global ICSR (WHO-UMC VigBase) database

Woongshik Nam1, 2, Ji-Hwan Bae1, Jeongin Oh1, Ju-Young Shin1, 3, 4, Hoon Kim1, 3, 5
1 School of Pharmacy, Sungkyunkwan University, Suwon-si, 2 Korea Institute of Drug Safety and Risk Management, Dongan-gu, Anyang-si, 3 Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon-si, Gyeonggi-do, 4 Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Gangnam-gu, Seoul, and 5 Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Republic of Korea

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DOI 10.5414/CP204580

Abstract

Objective: This study aimed to detect cardiovascular disease-related signals using Global Individual Case Safety Report data on JAK inhibitors.
Materials and methods: A signal detection study was conducted using the WHO-UMC VigiBase.
Results: This study identified four cardiovascular adverse event signals associated with JAK inhibitors in Asian populations, including pulmonary embolism, deep vein thrombosis, thrombosis, and cerebrovascular accidents.
Conclusion: Analysis of Asian populations revealed a higher risk of thromboembolic events associated with JAK inhibitors than with TNF inhibitors. However, unlike in the Western populations, no myocardial infarction signal was detected in the Asian populations.

Author Details

Authors

Departments

  • 1 School of Pharmacy, Sungkyunkwan University, Suwon-si,
  • 2 Korea Institute of Drug Safety and Risk Management, Dongan-gu, Anyang-si,
  • 3 Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon-si, Gyeonggi-do,
  • 4 Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Gangnam-gu, Seoul, and
  • 5 Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Republic of Korea

Address

Hoon Kim, PhD, Associate Professor
or
Ju-Young Shin, PhD, Associate Professor
School of Pharmacy
Sungkyunkwan University
2066, Seobu-ro, Jangan-gu, Suwon,
Gyeonggi-do 16419, South Korea
Email: [email protected]; [email protected]

Citation

Woongshik Nam, Ji-Hwan Bae, Jeongin Oh, Ju-Young Shin, Hoon Kim.Cardiovascular safety profile of JAK inhibitors and ethnic factors in Asians: A signal detection study using the Global ICSR (WHO-UMC VigBase) database
. Int J Clin Pharmacol Ther. 2025; 63: 160-163. doi: 10.5414/CP204580. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40013961/; PMID: 40013961.

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