Abstract

Introduction: Eosinophils play an important regulatory and immunomodulatory role in airway mucosa and have antiparasitic and antiviral properties as well as pro-inflammatory effects that may also cause persistence of inflammation with tissue remodeling. The number of eosinophils and the detection of specific mediators in biological samples from, e.g., blood, nasal secretions, and bronchial fluid can serve as biomarkers that reflect the underlying pathophysiology of certain diseases, predict treatment success, and detect therapy effects. Materials and methods: A literature search was conducted to determine the immunologic basis, mode of action, clinical significance, and available evidence for therapeutic approaches using eosinophil-targeted monoclonal antibodies by searching Medline, Pubmed, and the national and international trial database (ClinicalTrials.gov) and guideline registries as well as the Cochrane Library. Human studies published on the topic in the period up to and including 10/2023 were considered. Results: Based on the international literature and previous experience, the results are summarized, and recommendations are given. Conclusion: The important role of eosinophils in immunological processes in the airway mucosa is comprehensively analyzed and can serve as a basis for current and future treatment approaches.

Author Details

Authors

• Felix Klimek¹
• Christoph Bergmann²
• Jan Hagemann³
• Mandy Cuevas⁴
• Sven Becker⁵
• Oliver Pfaar⁶
• Ingrid Casper¹
• Ludger Klimek¹

Departments

• ¹ Center for Rhinology and Allergology, Wiesbaden,
• ² Practice for Ear, Nose and Throat disease, Clinic RKM
• ⁷ 
• ⁴ 
• ⁰ , Düsseldorf,
• ³ Department for Otolaryngology, University Medical Center Mainz, Mainz,
• ⁴ Department for Otolaryngology, University Hospital Carl Gustav Carus, TU Dresden, Dresden,
• ⁵ Department for Otolaryngology, University Hospital Tübingen, Tübingen, and
• ⁶ Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany

Address

Professor Dr. med. L. Klimek, Center for Rhinology and Allergology, An den Quellen 10, 65183 Wiesbaden, Germany
Email: [email protected]

Citation