Abstract

A 70-year-old male taking venlafaxine for depression developed interstitial pneumonia and was admitted with shortness of breath and dyspnea. A computed tomography (CT) chest scan showed diffuse multiple lung lesions in both lungs, suggesting interstitial changes with inflammation or exudation. Compared with the CT chest scan 1 month earlier, there were significant progresses and new findings. The clinical diagnosis was interstitial pneumonia with pulmonary infection. The patient had been treated with fluvoxamine 100 mg/day, duloxetine 60 mg/day, venlafaxine 75 mg/day for depression over the past 4 months. The exacerbation of interstitial pneumonia was suspected to be related to venlafaxine. Wheezing improved slightly after discontinuation of venlafaxine and treatment in the respiratory ICU. However, the patient could not tolerate the ICU environment, therefore became agitated, irritable, and anxious. Finally the patient gave up treatment and was discharged. Three months after discharge, the patient died of a sudden of interstitial pneumonia. A Naranjo assessment score of 3 was obtained, indicating a possible correlation between the patient’s adverse drug reaction and the suspect drug.

*These authors contributed equally to this study.

Author Details

Authors

• Xia Wu¹
• Lutao Zhang²*
• Chuanping Wang¹*

Departments

• ¹ Department of Pharmacy and
• ² Pulmonary and Critial Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China

Address

Lutao Zhang, MD

or
Chuanping Wang, MD
The Second Hospital of Hebei Medical University
No.215, West Heping Road
Shijiazhuang 050000, Hebei Province, China
Email: [email protected]; [email protected]

Citation