Abstract

Aims: Meningeal chondromas constitute a small fraction of central nervous system tumors, with only 61 cases reported in the literature. Somatic mutations of IDH1/2 genes have been described in enchondromas, and, in soft-tissue chondromas, rearrangements of the HMGA2 gene have been reported. The aim of our study was to perform molecular analyses of 3 additional cases and to do a complete review of the literature to better characterize this rare entity.
Materials and methods: Here, we report 3 cases of primitive meningeal chondromas in children and young adults. Immunohistochemical analyses for HMGA2 and IDH1R132H, molecular analyses of IDH1/2 mutations, and FISH analysis of the HMGA2 locus were performed.
Results: Immunohistochemical analyses of all cases were negative for IDH1R132H and HMGA2 proteins. Molecular analyses failed to reveal IDH1/2 mutations, and FISH analyses did not evidence any HMGA2 rearrangements. Similarly to what is reported in the literature, the 3 meningeal chondromas in this study were benign tumors with no recurrence after complete resection with a follow-up of 85, 46, and 89 months.
Conclusion: Meningeal chondroma is rare. It affects predominantly young adults and has a good outcome. No molecular alterations have currently been described in this entity.

Author Details

Authors

• Arnault Tauziède-Espariat¹
• Fanny Burel-Vandenbos^{2, 3}
• Florence Pedeutour³
• Albane Gareton¹
• Raphaël Saffroy⁴
• Felipe Andreiuolo¹
• Thomas Blauwblomme⁵
• Volodia Dangouloff-Ros⁶
• Nathalie Boddaert⁶
• Emmanuèle Lechapt¹
• Fabrice Chrétien¹
• Pascale Varlet¹

Departments

• ¹ GHU Paris Psychiatrie Neurosciences, Sainte-Anne Hospital, Department of Neuropathology, Paris,
• ² Pasteur I University Hospital, Central Laboratory of Pathology,
• ³ Centre Hospitalier Universitaire de Nice, Faculté de Médecine, Laboratory of Solid Tumors Genetics, Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR
• ⁷ 
• ² 
• ⁸ 
• ⁴ /INSERM U
• ¹ 
• ⁰ 
• ⁸ 
• ¹ , Université Côte d’Azur (UCA), Nice,
• ⁴ Paul Brousse Hospital, Department of Biochemistry and Oncogenetics, Villejuif,
• ⁵ Necker University Hospital, Department of Pediatric Neurosurgery,
• ⁶ Necker University Hospital, Department of Radiology, Paris, France

Address

Arnault Tauziède-Espariat, MD
GHU Paris Psychiatrie Neurosciences
Sainte-Anne Hospital
Department of Neuropathology
1, Rue Cabanis, 75014 Paris
Email: [email protected]

Citation