Abstract

The aim of the study was to assess the complex response of rats to supplementation of various forms (Cr2O3 nanoparticle (NP), picolinate (CrPic) and CrCl3) and doses (300 and 500 µg/kg) of chromium in the diet of rats. The maximal daily weight gain was observed in rats fed with NP (p ≤ 0.05). The number of erythrocytes and hemoglobin in groups receiving chromium at a dose of 300 µg/kg increased in association with moderate leukocytosis (p ≤ 0.05). A a dose of 500 µg/kg of NP resulted in decreased ALT activity. The intake of CrCl3 (500 µg/kg) contributed to a decrease in the activity of AST in the blood serum, whereas it was increased in response to Cr2O3 and CrPic (300 and 500 µg/kg) administration (p ≤ 0.05). Stimulation of the activity of amylase and protease was observed in NP-treated animals, and a decrease was induced by CrCl3 (500 µg/kg) and CrPic (300 µg/kg). The reaction of the intestinal microbiota was characterized by the growth of enterobacteria, lactobacilli at day 14 except for the groups receiving CrPic 300 and NP 500 µg/kg; the number of bifidobacteria decreased in all experimental groups, except for CrCl3 and CrPic (500 µg/kg). Therefore, 300 and 500 µg/kg NP can be used as an antibacterial agent and as growth and hemopoiesis stimulant.

Author Details

Authors

• Svyatoslav Lebedev^{1, 2}
• Irina Gavrish^{1, 2}
• Elena Rusakova^{1, 2}
• Olga Kvan^{1, 2}
• Ilmira Gubaidullina¹

Departments

• ¹ Federal Scientific Center “Biological Systems and Agrotechnologies RAS” and
• ² Orenburg State University, Orenburg, Russia

Address

Svyatoslav Lebedev, PhD, DSc
Federal Scientific Center “Biological Systems and Agrotechnologies RAS”
January 9 St., 29, Orenburg, 460000, Russia
Email: [email protected]

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