Abstract

Plasma and salivary amoxicillin (AMO) concentrations were quantified following a single oral dose (875 mg) of two formulations of AMO (Amoxicillin-EMS Sigma Pharma and Amoxil BD 875 mg). In addition, the effect of amoxicillin against oral microorganisms was accessed. The open, randomized, two-period crossover study was carried out in 20 volunteers. Saliva and blood samples were collected at 0, 0.5, 1, 2, 4, 8 and 12 h after drug administration, and quantified using HPLC-ESI-MS and HPLC, respectively. Streptococci counts, anaerobe counts and total microorganism counts were obtained. No differences were observed between formulations (p > 0.05) in the plasma and salivary AMO concentrations and the pharmacokinetic parameters (Cmax, tmax, AUC0–8, and AUC0–¥) also showed no statistically significant differences between formulations (p > 0.05). Microorganism counts for the two formulations at all sampling times did not differ (p > 0.05) but all microorganism counts at 60 min post-dose showed a significant decrease (p < 0.05). Amoxicillin was effective in reducing oral microorganism levels up to 12 h post-dose.

Author Details

Authors

• S. Baglie
• A.P. Del Bortolo Ruenis
• R.H. Lopes Motta
• R.C. Catelli Baglie
• G.C. Nobre Franco
• L.M. Franco
• P.L. Rosalen
• P. Silva
• F.C. Groppo

Departments

• ¹ Department of Pharmaceutical Sciences, Ponta Grossa State University, Ponta Grossa, PR,
• ² Piracicaba Dental School, State University of Campinas, Area of Pharmacology, Anesthesiology and Therapeutics, Piracicaba, SP,
• ³ Department of Pharmacology, Anesthesiology and Therapeutics, Sao Leopoldo Dentistry School, Campinas, SP,
• ⁴ Faculty of Health Sciences, Methodist University of Piracicaba, UNIMEP, Piracicaba, SP, and
• ⁵ Bioagri Laboratories Ltda, Piracicaba, SP, Brazil

Address

Prof. F.C. Groppo, Piracicaba Dental School, State University of Campinas, Area of Pharmacology, Anesthesiology and Therapeutics,
Av. Limeira, 901, Bairro Areiao, 13414-903 Piracicaba, SP, Brazil
Email: [email protected]

Citation