Abstract

This meta-analysis was conducted to evaluate the effect of statins on the lipid profile in pediatric and adolescent patients with familial hypercholesterolemia (FH). Randomized, double-blind, controlled trials comparing statins with placebo were identified through electronic and manual search; percent reductions from baseline were calculated for various lipid parameters. Standardized mean differences (effect size) with 95% confidence interval (CI) were calculated for each study and pooled effect size was calculated. A total of 6 studies were included in the meta-analysis. As compared to placebo, statins caused a significant decrease in total cholesterol (TC) [–3.11% (95% CI –3.46 to –2.99)], low-density lipoprotein (LDL) [–4.01% (95% CI –4.27 to –3.81)], triglyceride (TG) [–1.41 (95% CI –1.66 to –1.26)] and a significant increase in high-density lipoprotein (HDL) [1.12 (95% CI 0.73 – 1.13)]. In conclusion, statins were shown to have good efficacy for the treatment of FH in children.

Author Details

Authors

• N. Shafiq
• B. Bhasin
• S. Pattanaik
• P. Pandhi
• S.P. Venkateshan
• M. Singh
• S. Malhotra

Departments

• ¹ Department of Pharmacology,
• ² Department of Pediatrics, PGIMER, Chandigarh, India

Address

Dr. S. Malhotra, Department of Pharmacology, PGIMER, Chandigarh, 160012, India
Email: [email protected]

Citation